Blockade of soluble epoxide hydrolase attenuates post-ischemic neuronal hyperexcitation and confers resilience against stroke with TrkB activation

Inhibition and deletion of soluble epoxide hydrolase (sEH) has been suggested to ameliorate infarction in experimental ischemic stroke possibly via vasoactive epoxyeicosatrienoic acids. However, it is unknown whether the neuroprotective mechanisms involve alteration of post-ischemic neuronal transmi...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.118-118, Article 118
Hauptverfasser:	Chang, Li-Hsin, Lin, Hui-Ching, Huang, Shiang-Suo, Chen, I-Chih, Chu, Kai-Wen, Chih, Chun-Lien, Liang, Yao-Wen, Lee, Yi-Chung, Chen, You-Yin, Lee, Yi-Hsuan, Lee, I-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/51 14/19 631/378/1689/534 631/378/2607 64/60 82/80 9/30 Animals Cerebral blood flow Cerebral Cortex - blood supply Cerebral Cortex - metabolism Cerebral Cortex - pathology Cerebral infarction Disease Models, Animal Enzyme Activation Epoxide hydrolase Epoxide Hydrolases - antagonists & inhibitors Epoxide Hydrolases - deficiency Excitatory Postsynaptic Potentials Gene Deletion Glucose Glutamic acid receptors Hippocampus Hippocampus - metabolism Humanities and Social Sciences Immunohistochemistry Ischemia Long-term potentiation Male Membrane Glycoproteins - metabolism Mice Mice, Knockout Microvasculature Motor Activity multidisciplinary Neurological diseases Neurons - metabolism Neuroprotection Neuroprotective Agents Oxygen Protein-Tyrosine Kinases - metabolism Psychomotor Performance Rodents Science Science (multidisciplinary) Sensorimotor system Staphylococcal enterotoxin H Stroke Stroke - etiology Stroke - metabolism Stroke - physiopathology Synaptic Transmission TrkB receptors Tropomyosin Vasoactive agents
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