Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica

Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG), an antibody that selectively binds to the aquaporin-4. Here, we established a localized NMO model by injecting NMO-IgG into the spinal cord, and assessed the efficacy of treating its NMO-like symptoms...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.34-34, Article 34
Hauptverfasser:	Harada, Kana, Fujita, Yuki, Okuno, Tatsusada, Tanabe, Shogo, Koyama, Yoshihisa, Mochizuki, Hideki, Yamashita, Toshihide
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 38/1 631/378/340 631/378/371 64/60 Animals Antibodies Aquaporin 4 Aquaporin 4 - genetics Aquaporin 4 - metabolism Aquaporins Astrocytes Astrocytes - metabolism Autoimmune diseases Autoimmunity Axon guidance CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Disease Disease Models, Animal Drug dosages Gene Expression Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism GPI-Linked Proteins Humanities and Social Sciences Humans Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin G - pharmacology Immunoglobulins Inflammation Membrane Proteins - antagonists & inhibitors Membrane Proteins - immunology multidisciplinary Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - immunology Neuromyelitis Neuromyelitis Optica - diagnosis Neuromyelitis Optica - drug therapy Neuromyelitis Optica - immunology Neuromyelitis Optica - metabolism Neurons - immunology Neurons - metabolism Neurosciences Rats Rodents Science Science (multidisciplinary) Severity of Illness Index Spinal cord Spinal Cord - immunology Spinal Cord - metabolism Spinal Cord - pathology Th17 Cells - immunology Th17 Cells - metabolism Vertebrae
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