Bortezomib inhibits proliferation, migration, and TGF-β1-induced epithelial-mesenchymal transition of RPE cells

Nuclear factor kappa B (NF-κB) plays an important role in the epithelial-mesenchymal transition (EMT) of RPE cells. We investigated the effects of a proteasome inhibitor, bortezomib, on the EMT in RPE cells. In addition, we assessed the influence of bortezomib on regulation of the NF-κB pathway duri...

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Veröffentlicht in:	Molecular vision 2017, Vol.23, p.1029-1038
Hauptverfasser:	Moon, Kun, Lee, Hyun-Gyo, Baek, Won-Ki, Lee, Youngkyun, Kim, Kwang Soo, Jun, Jong Hwa, Kim, Jae-Young, Joo, Choun-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Bortezomib Cell adhesion & migration Cell migration Cell proliferation Collagen Contraction Flow cytometry Mesenchyme NF-κB protein Proteasome inhibitors Retina Signal transduction Tetrazolium salt Transforming growth factor Transforming growth factor-b1 Wound healing
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