Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke

We sought to investigate the relationship between blood–brain barrier (BBB) permeability and microstructural white matter integrity, and their potential impact on long-term functional outcomes in patients with acute ischemic stroke (AIS). We studied 184 AIS subjects with perfusion-weighted MRI (PWI)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2018-01, Vol.38 (1), p.75-86
Hauptverfasser:	Rost, Natalia S, Cougo, Pedro, Lorenzano, Svetlana, Li, Hua, Cloonan, Lisa, Bouts, Mark JRJ, Lauer, Arne, Etherton, Mark R, Karadeli, Hasan H, Musolino, Patricia L, Copen, William A, Arai, Ken, Lo, Eng H, Feske, Steve K, Furie, Karen L, Wu, Ona
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Blood-Brain Barrier - diagnostic imaging Blood-Brain Barrier - pathology Brain Ischemia - blood Brain Ischemia - diagnostic imaging Brain Ischemia - pathology Capillary Permeability Female Humans Image Interpretation, Computer-Assisted Magnetic Resonance Angiography Male Matrix Metalloproteinase 2 - blood Middle Aged Original Prognosis Recovery of Function Stroke - blood Stroke - diagnostic imaging Stroke - pathology White Matter - diagnostic imaging White Matter - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We sought to investigate the relationship between blood–brain barrier (BBB) permeability and microstructural white matter integrity, and their potential impact on long-term functional outcomes in patients with acute ischemic stroke (AIS). We studied 184 AIS subjects with perfusion-weighted MRI (PWI) performed
ISSN:	0271-678X 1559-7016
DOI:	10.1177/0271678X17706449