Smad3‐mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial–mesenchymal transition

During epithelial–mesenchymal transition (EMT), reprogramming of gene expression is accompanied by histone modifications. Whether EMT‐promoting signaling directs functional changes in histone methylation has not been established. We show here that the histone lysine methyltransferase SETDB1 represse...

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Veröffentlicht in:	EMBO reports 2018-01, Vol.19 (1), p.135-155
Hauptverfasser:	Du, Dan, Katsuno, Yoko, Meyer, Dominique, Budi, Erine H, Chen, Si‐Han, Koeppen, Hartmut, Wang, Hongjun, Akhurst, Rosemary J, Derynck, Rik
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer cancer cell dissemination cancer drug resistance Carcinoma, Ductal - genetics Carcinoma, Ductal - metabolism Carcinoma, Ductal - pathology Cell Line, Tumor Chromatin DNA methylation EMBO03 EMBO09 Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology epithelial stem cells Epithelial-Mesenchymal Transition - genetics Event-related potentials Female Gene expression Gene Expression Regulation, Neoplastic Gene silencing histone methylation Histone-Lysine N-Methyltransferase Histones - genetics Histones - metabolism Humans Lysine Mammary Glands, Animal - metabolism Mammary Glands, Animal - pathology Mammary Glands, Human - metabolism Mammary Glands, Human - pathology Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mesenchyme Metastases Methylation Methyltransferase Mice Protein Methyltransferases - genetics Protein Methyltransferases - metabolism Protein Processing, Post-Translational Recruitment Signal Transduction Signaling Smad protein Smad3 protein Smad3 Protein - genetics Smad3 Protein - metabolism Smad4 Protein - genetics Smad4 Protein - metabolism Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Snail protein Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Stem cells TGF‐β signaling Transforming Growth Factor beta - pharmacology
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