Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria

Riboswitches and attenuators are cis-regulatory RNA elements, most of which control bacterial gene expression via metabolite-mediated, premature transcription termination. We developed an unbiased experimental approach for genome-wide discovery of such ribo-regulators in bacteria. We also devised an...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2016-04, Vol.352 (6282), p.aad9822-aad9822
Hauptverfasser:	Dar, Daniel, Shamir, Maya, Mellin, J R, Koutero, Mikael, Stern-Ginossar, Noam, Cossart, Pascale, Sorek, Rotem
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Anti-Bacterial Agents - pharmacology Bacillus subtilis - drug effects Bacillus subtilis - genetics Drug Resistance, Bacterial - genetics Enterococcus faecalis - drug effects Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - genetics Gene Expression Regulation, Bacterial Genome, Bacterial - genetics Genome-Wide Association Study - methods High-Throughput Nucleotide Sequencing - methods Humans Listeria monocytogenes - drug effects Listeria monocytogenes - genetics Ribosomes - metabolism Riboswitch - genetics Sequence Analysis, RNA - methods Transcription Termination, Genetic
Online-Zugang:	Volltext
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