Process analytical quality control of tailored drug release formulation prepared via hot-melt extrusion technology

The objective of the present study was to compare the influence of Eudragit® RS PO and RL PO blends on the release of water-soluble and insoluble drugs from hot-melt extruded formulations. In addition, we aimed to evaluate drug content uniformity and distribution by Fourier transform-infrared (FT-IR...

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Veröffentlicht in:	Journal of drug delivery science and technology 2017-04, Vol.38, p.51-58
Hauptverfasser:	Park, Jun-Bom, Lee, Beom-Jin, Kang, Chin-Yang, Tiwari, Roshan V., Repka, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Eudragit FT-IR imaging Hot-melt extrusion Process analytical technology (PAT) Sustained drug release
Online-Zugang:	Volltext
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