In vivo and in vitro induction of the apoptotic effects of oxysophoridine on colorectal cancer cells via the Bcl-2/Bax/caspase-3 signaling pathway

Oxysophoridine (OSR) is a major active alkaloid extracted from Sophoraalopecuroides L. The aim of the present study was to investigate the induction of the apoptotic effects of OSR on colorectal cancer cells in vivo and in vitro. The results of the MTT and colony formation assays demonstrated that t...

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Veröffentlicht in:	Oncology letters 2017-12, Vol.14 (6), p.8000-8006
Hauptverfasser:	Jin, Shao-Ju, Yang, Yun, Ma, Lei, Ma, Ben-Hui, Ren, Li-Ping, Guo, Liu-Cheng, Wang, Wen-Bao, Zhang, Yan-Xin, Zhao, Zhi-Jun, Cui, Mingchen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Alkaloids Apoptosis B-cell lymphoma-2 B-cell lymphoma-2-associated X protein Beans Cancer therapies Care and treatment caspase-3 Cell growth Cellular signal transduction Colorectal cancer Cytochrome Development and progression Health aspects Herbal medicine Legumes Lymphoma Mimosaceae Mortality Oncology oxysophoridine Proteins Studies Tumors
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