PANDER KO mice on high-fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia

The recent creation of the PANDER (pancreatic-derived factor) knockout (PANKO) and acute mouse models have revealed a biological function in the regulation of glycemic levels via promotion of hepatic glucose production (HGP) and pancreatic β-cell insulin secretion. Therefore, we hypothesized that th...

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Veröffentlicht in:	FEBS letters 2011-05, Vol.585 (9), p.1345-1349
Hauptverfasser:	Robert-Cooperman, Claudia E., Wilson, Camella G., Burkhardt, Brant R.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Blood Glucose - metabolism Body Weight Cytokines - deficiency Cytokines - genetics Dietary Fats - administration & dosage Dietary Fats - toxicity Enzyme-Linked Immunosorbent Assay fasting Fasting - blood G6pase Glucose Glucose - metabolism Glucose Intolerance - blood Glucose Intolerance - etiology Glucose Intolerance - genetics Glucose Tolerance Test glucose tolerance tests glucose-6-phosphatase glucose-stimulated insulin secretion glycemic index GSIS GTT hepatic glucose production HFD HGP high fat diet Hyperglycemia Hyperglycemia - blood Hyperglycemia - etiology Hyperglycemia - genetics hyperinsulinemia Hyperinsulinism - blood Hyperinsulinism - etiology Hyperinsulinism - genetics Insulin Insulin - blood insulin secretion insulin tolerance tests islets of Langerhans ITT Liver - drug effects Liver - metabolism Mice Mice, Knockout Pancreatic-derived factor PANDER PEPCK phosphoenolpyruvate carboxykinase T2DM type 2 diabetes mellitus
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