Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum Surface Antigens and Possible Vaccine Candidates

Despite recent efforts toward control and elimination, malaria remains a major public health problem worldwide. Plasmodium falciparum resistance against artemisinin, used in front line combination drugs, is on the rise, and the only approved vaccine shows limited efficacy. Combinations of novel and...

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Veröffentlicht in:	Molecular & cellular proteomics 2018-01, Vol.17 (1), p.43-60
Hauptverfasser:	Nilsson Bark, Sandra K., Ahmad, Rushdy, Dantzler, Kathleen, Lukens, Amanda K., De Niz, Mariana, Szucs, Matthew J., Jin, Xiaoying, Cotton, Joanne, Hoffmann, Dietmar, Bric-Furlong, Eva, Oomen, Ray, Parrington, Mark, Milner, Dan, Neafsey, Daniel E., Carr, Steven A., Wirth, Dyann F., Marti, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Protozoan - immunology Antigens, Surface - immunology Artemisinin Binding Blood Cell Membrane - immunology Cell surface Drugs Epitopes Erythrocytes Erythrocytes - immunology Female Genomes Immunology Infections Malaria Malaria Vaccines Mice, Inbred BALB C Next-generation sequencing Nucleotide sequence Parasites Plasmodium falciparum Plasmodium falciparum - immunology Proteins Proteome Proteomics Public health Receptors Surface antigens Tropism Vaccination Vaccines Vector-borne diseases
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