The correlations between serum amphiregulin and other clinicopathological factors in colorectal cancer
Amphiregulin (AREG) is one of the epidermal growth factor receptor (EGFR) ligands and plays the important roles in tumor progression and metastasis. Upregulation of AREG in colorectal cancer (CRC) tissues has been shown to correlate with depth of tumor invasion, nerve invasion and liver metastasis....
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| Veröffentlicht in: | Journal of gastrointestinal oncology 2017-12, Vol.8 (6), p.980-984 |
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| container_title | Journal of gastrointestinal oncology |
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| creator | Chayangsu, Chawalit Khunsri, Siriporn Sriuranpong, Virote Tanasanvimon, Suebpong |
| description | Amphiregulin (AREG) is one of the epidermal growth factor receptor (EGFR) ligands and plays the important roles in tumor progression and metastasis. Upregulation of AREG in colorectal cancer (CRC) tissues has been shown to correlate with depth of tumor invasion, nerve invasion and liver metastasis. We sought to investigate a correlation of serum AREG in CRC with clinicopathological parameters.
Patients with CRC receiving treatment at King Chulalongkorn Memorial Hospital during August 2013 to March 2014 were enrolled. We collected baseline serum prior to start any therapy and stored till analysis. Serum AREG was measured by ELISA. The correlation between each clinicopathological characteristic and serum AREG was analysed.
There were 120 patients with CRC including 78 patients (65.0%) with stage I-III and 41 patients (34.2%) in stage IV or recurrent disease. In stage IV or recurrent group, the median level of serum AREG was 31.55 pg/mL, which was higher than those of stage I-III group, 15.48 pg/mL, P=0.001. The serum AREG higher than 25 pg/mL (high serum AREG) was significantly correlated with liver and peritoneal metastasis (P |
| doi_str_mv | 10.21037/jgo.2017.08.15 |
| format | Article |
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Patients with CRC receiving treatment at King Chulalongkorn Memorial Hospital during August 2013 to March 2014 were enrolled. We collected baseline serum prior to start any therapy and stored till analysis. Serum AREG was measured by ELISA. The correlation between each clinicopathological characteristic and serum AREG was analysed.
There were 120 patients with CRC including 78 patients (65.0%) with stage I-III and 41 patients (34.2%) in stage IV or recurrent disease. In stage IV or recurrent group, the median level of serum AREG was 31.55 pg/mL, which was higher than those of stage I-III group, 15.48 pg/mL, P=0.001. The serum AREG higher than 25 pg/mL (high serum AREG) was significantly correlated with liver and peritoneal metastasis (P<0.001). Additionally, high serum AREG was significantly correlated with more poor differentiated/mucinous histological grade (P=0.014), distant metastasis (P=0.001), lymphovascular invasion (P=0.016) and perineural invasion (P<0.001).
High serum AREG was associated with advanced diseases and poor pathologic factors in CRC. It is potentially a prognostic marker in CRC.</description><identifier>ISSN: 2078-6891</identifier><identifier>EISSN: 2219-679X</identifier><identifier>DOI: 10.21037/jgo.2017.08.15</identifier><identifier>PMID: 29299357</identifier><language>eng</language><publisher>China: AME Publishing Company</publisher><subject>Original</subject><ispartof>Journal of gastrointestinal oncology, 2017-12, Vol.8 (6), p.980-984</ispartof><rights>2017 Journal of Gastrointestinal Oncology. All rights reserved. 2017 Journal of Gastrointestinal Oncology.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-cc040e9503ca505e27915dda0334479229acf79c7dd7c82eaa4d915a279d2c0a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750193/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750193/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29299357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chayangsu, Chawalit</creatorcontrib><creatorcontrib>Khunsri, Siriporn</creatorcontrib><creatorcontrib>Sriuranpong, Virote</creatorcontrib><creatorcontrib>Tanasanvimon, Suebpong</creatorcontrib><title>The correlations between serum amphiregulin and other clinicopathological factors in colorectal cancer</title><title>Journal of gastrointestinal oncology</title><addtitle>J Gastrointest Oncol</addtitle><description>Amphiregulin (AREG) is one of the epidermal growth factor receptor (EGFR) ligands and plays the important roles in tumor progression and metastasis. Upregulation of AREG in colorectal cancer (CRC) tissues has been shown to correlate with depth of tumor invasion, nerve invasion and liver metastasis. We sought to investigate a correlation of serum AREG in CRC with clinicopathological parameters.
Patients with CRC receiving treatment at King Chulalongkorn Memorial Hospital during August 2013 to March 2014 were enrolled. We collected baseline serum prior to start any therapy and stored till analysis. Serum AREG was measured by ELISA. The correlation between each clinicopathological characteristic and serum AREG was analysed.
There were 120 patients with CRC including 78 patients (65.0%) with stage I-III and 41 patients (34.2%) in stage IV or recurrent disease. In stage IV or recurrent group, the median level of serum AREG was 31.55 pg/mL, which was higher than those of stage I-III group, 15.48 pg/mL, P=0.001. The serum AREG higher than 25 pg/mL (high serum AREG) was significantly correlated with liver and peritoneal metastasis (P<0.001). Additionally, high serum AREG was significantly correlated with more poor differentiated/mucinous histological grade (P=0.014), distant metastasis (P=0.001), lymphovascular invasion (P=0.016) and perineural invasion (P<0.001).
High serum AREG was associated with advanced diseases and poor pathologic factors in CRC. It is potentially a prognostic marker in CRC.</description><subject>Original</subject><issn>2078-6891</issn><issn>2219-679X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkc1LHjEQxkNRqqjn3kqOXvY1HxuzuRRE7AcIXhS8hXF29t3I7uZtkm3pf2-qVmouk8z85skDD2OfpNgoKbQ9e9zGjRLSbkS3keYDO1RKuubcuvu9ehe2a847Jw_YSc6Pop7WGWHUR3agnHJOG3vIhtuROMaUaIIS4pL5A5XfRAvPlNaZw7wbQ6LtOoWFw9LzWEZKHOszYNxBGeMUtwFh4gNgiSnzCmJtJsJSuwgLUjpm-wNMmU5e6xG7-3p1e_m9ub759uPy4rpB7XRpEEUrqLrUCNUqKeuk6XsQWretdUo5wME6tH1vsVME0PaVgMr1CgXoI_blRXe3PszUIy0lweR3KcyQ_vgIwb-fLGH02_jLG2uEdLoKnL4KpPhzpVz8HDLSNMFCcc1euq61RppWVvTsBcUUc040vH0jhX8OyNeA_N-AvOi8NHXj8__u3vh_cegnm2SPtQ</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Chayangsu, Chawalit</creator><creator>Khunsri, Siriporn</creator><creator>Sriuranpong, Virote</creator><creator>Tanasanvimon, Suebpong</creator><general>AME Publishing Company</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201712</creationdate><title>The correlations between serum amphiregulin and other clinicopathological factors in colorectal cancer</title><author>Chayangsu, Chawalit ; Khunsri, Siriporn ; Sriuranpong, Virote ; Tanasanvimon, Suebpong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-cc040e9503ca505e27915dda0334479229acf79c7dd7c82eaa4d915a279d2c0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Chayangsu, Chawalit</creatorcontrib><creatorcontrib>Khunsri, Siriporn</creatorcontrib><creatorcontrib>Sriuranpong, Virote</creatorcontrib><creatorcontrib>Tanasanvimon, Suebpong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastrointestinal oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chayangsu, Chawalit</au><au>Khunsri, Siriporn</au><au>Sriuranpong, Virote</au><au>Tanasanvimon, Suebpong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The correlations between serum amphiregulin and other clinicopathological factors in colorectal cancer</atitle><jtitle>Journal of gastrointestinal oncology</jtitle><addtitle>J Gastrointest Oncol</addtitle><date>2017-12</date><risdate>2017</risdate><volume>8</volume><issue>6</issue><spage>980</spage><epage>984</epage><pages>980-984</pages><issn>2078-6891</issn><eissn>2219-679X</eissn><abstract>Amphiregulin (AREG) is one of the epidermal growth factor receptor (EGFR) ligands and plays the important roles in tumor progression and metastasis. Upregulation of AREG in colorectal cancer (CRC) tissues has been shown to correlate with depth of tumor invasion, nerve invasion and liver metastasis. We sought to investigate a correlation of serum AREG in CRC with clinicopathological parameters.
Patients with CRC receiving treatment at King Chulalongkorn Memorial Hospital during August 2013 to March 2014 were enrolled. We collected baseline serum prior to start any therapy and stored till analysis. Serum AREG was measured by ELISA. The correlation between each clinicopathological characteristic and serum AREG was analysed.
There were 120 patients with CRC including 78 patients (65.0%) with stage I-III and 41 patients (34.2%) in stage IV or recurrent disease. In stage IV or recurrent group, the median level of serum AREG was 31.55 pg/mL, which was higher than those of stage I-III group, 15.48 pg/mL, P=0.001. The serum AREG higher than 25 pg/mL (high serum AREG) was significantly correlated with liver and peritoneal metastasis (P<0.001). Additionally, high serum AREG was significantly correlated with more poor differentiated/mucinous histological grade (P=0.014), distant metastasis (P=0.001), lymphovascular invasion (P=0.016) and perineural invasion (P<0.001).
High serum AREG was associated with advanced diseases and poor pathologic factors in CRC. It is potentially a prognostic marker in CRC.</abstract><cop>China</cop><pub>AME Publishing Company</pub><pmid>29299357</pmid><doi>10.21037/jgo.2017.08.15</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| title | The correlations between serum amphiregulin and other clinicopathological factors in colorectal cancer |
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