Cryo-EM structures of the TMEM16A calcium-activated chloride channel

Electron cryo-microscopy density maps of mouse TMEM16A reconstituted in nanodiscs or solubilized in detergent reveal two functional states of calcium-activated chloride channels. TMEM16A structure solved The diverse TMEM16 membrane protein family contains Ca( II )-activated chloride channels, lipid...

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Veröffentlicht in:	Nature (London) 2017-12, Vol.552 (7685), p.426-429
Hauptverfasser:	Dang, Shangyu, Feng, Shengjie, Tien, Jason, Peters, Christian J., Bulkley, David, Lolicato, Marco, Zhao, Jianhua, Zuberbühler, Kathrin, Ye, Wenlei, Qi, Lijun, Chen, Tingxu, Craik, Charles S., Jan, Yuh Nung, Minor, Daniel L., Cheng, Yifan, Jan, Lily Yeh
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/535/1258/1259 631/57/2270/1140 82 82/1 82/80 82/83 9/74 Analysis Animals Anions - chemistry Anions - metabolism Anoctamin-1 - chemistry Anoctamin-1 - metabolism Anoctamin-1 - ultrastructure Calcium - chemistry Calcium - metabolism Calcium - pharmacology Cell receptors Chloride channels Cryoelectron Microscopy Glucosides - chemistry HEK293 Cells Humanities and Social Sciences Humans Ion Channel Gating - drug effects Ion Transport - drug effects letter Mice Models, Molecular multidisciplinary Nanostructures - chemistry Nanostructures - ultrastructure Protein Conformation - drug effects Science
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