FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction

Foods high in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) exacerbate symptoms of irritable bowel syndrome (IBS); however, their mechanism of action is unknown. We hypothesized that a high-FODMAP (HFM) diet increases visceral nociception by inducing dysbiosis a...

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Veröffentlicht in:	The Journal of clinical investigation 2018-01, Vol.128 (1), p.267-280
Hauptverfasser:	Zhou, Shi-Yi, Gillilland, 3rd, Merritt, Wu, Xiaoyin, Leelasinjaroen, Pornchai, Zhang, Guanpo, Zhou, Hui, Ye, Bo, Lu, Yuanxu, Owyang, Chung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Bacteria Breath tests Colon Cytokines Diet Dietary Carbohydrates - adverse effects Dietary Carbohydrates - pharmacology Digestive system Disaccharides Dysbacteriosis Dysbiosis - chemically induced Dysbiosis - genetics Dysbiosis - metabolism Dysbiosis - microbiology Feces Fermented food Gastrointestinal Microbiome Gastrointestinal tract Gene Knockdown Techniques Health aspects Hyperalgesia Hypotheses Inflammation Intestine Intestines - microbiology Irritable bowel syndrome Irritable Bowel Syndrome - chemically induced Irritable Bowel Syndrome - genetics Irritable Bowel Syndrome - metabolism Irritable Bowel Syndrome - microbiology Lipopolysaccharides Lipopolysaccharides - toxicity Male Microbiota Monosaccharides Nociception Nutrient deficiency Oligosaccharides Pain perception Pathology Permeability Polyols Rats Rats, Wistar TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors
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