GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC50 and Basal Activity

The concerted transition model for multimeric proteins is a simple formulation for analyzing the behavior of transmitter-gated ion channels. We used the model to examine the relationship between the EC50 for activation of the GABA type A (GABAA) receptor by the transmitter GABA and basal activity em...

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Veröffentlicht in:	Molecular pharmacology 2018-02, Vol.93 (2), p.90-100
Hauptverfasser:	Akk, Gustav, Shin, Daniel J., Germann, Allison L., Steinbach, Joe Henry
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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