Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome
This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants we...
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| Veröffentlicht in: | Nutrients 2017-11, Vol.9 (12), p.1280 |
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| creator | Jamilian, Mehri Foroozanfard, Fatemeh Rahmani, Elham Talebi, Maesoomeh Bahmani, Fereshteh Asemi, Zatollah |
| description | This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (
= 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (-0.2 ± 0.2 vs. -0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively,
= 0.02), free androgen index (FAI) (-0.06 ± 0.12 vs. -0.02 ± 0.12 and +0.004 ± 0.04, respectively,
= 0.04), hirsutism (-1.1 ± 1.1 vs. -0.8 ± 1.2 and -0.1 ± 0.4, respectively,
= 0.001) and high-sensitivity C-reactive protein (hs-CRP) (-0.7 ± 1.4 vs. -0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively,
= 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively,
< 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and -36 ± 104 mmol/L, respectively,
< 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups. |
| doi_str_mv | 10.3390/nu9121280 |
| format | Article |
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= 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (-0.2 ± 0.2 vs. -0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively,
= 0.02), free androgen index (FAI) (-0.06 ± 0.12 vs. -0.02 ± 0.12 and +0.004 ± 0.04, respectively,
= 0.04), hirsutism (-1.1 ± 1.1 vs. -0.8 ± 1.2 and -0.1 ± 0.4, respectively,
= 0.001) and high-sensitivity C-reactive protein (hs-CRP) (-0.7 ± 1.4 vs. -0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively,
= 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively,
< 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and -36 ± 104 mmol/L, respectively,
< 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu9121280</identifier><identifier>PMID: 29186759</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adolescent ; Adult ; Androgens - blood ; Anthropometry ; antioxidant activity ; Antioxidants ; Biomarkers - blood ; Blood Glucose - metabolism ; blood serum ; C-reactive protein ; C-Reactive Protein - metabolism ; Diet ; Dietary Carbohydrates - administration & dosage ; Dietary Fats - administration & dosage ; Dietary Fiber - administration & dosage ; Dietary Proteins - administration & dosage ; Dietary Supplements ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Globulins ; Hirsutism ; Humans ; Insulin ; Insulin Resistance ; Metabolism ; Metabolome ; Nutrition Assessment ; Oxidative Stress - drug effects ; patients ; placebos ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - drug therapy ; sex hormone-binding globulin ; Sex Hormone-Binding Globulin - metabolism ; sex reversal ; Testosterone ; Testosterone - blood ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - blood ; women ; Young Adult</subject><ispartof>Nutrients, 2017-11, Vol.9 (12), p.1280</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-62660490cfdbbd0a04a35a96a41521b00bf10a3a119aa0a524879f7b456e95243</citedby><cites>FETCH-LOGICAL-c436t-62660490cfdbbd0a04a35a96a41521b00bf10a3a119aa0a524879f7b456e95243</cites><orcidid>0000-0001-5265-4792</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748731/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748731/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29186759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jamilian, Mehri</creatorcontrib><creatorcontrib>Foroozanfard, Fatemeh</creatorcontrib><creatorcontrib>Rahmani, Elham</creatorcontrib><creatorcontrib>Talebi, Maesoomeh</creatorcontrib><creatorcontrib>Bahmani, Fereshteh</creatorcontrib><creatorcontrib>Asemi, Zatollah</creatorcontrib><title>Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (
= 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (-0.2 ± 0.2 vs. -0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively,
= 0.02), free androgen index (FAI) (-0.06 ± 0.12 vs. -0.02 ± 0.12 and +0.004 ± 0.04, respectively,
= 0.04), hirsutism (-1.1 ± 1.1 vs. -0.8 ± 1.2 and -0.1 ± 0.4, respectively,
= 0.001) and high-sensitivity C-reactive protein (hs-CRP) (-0.7 ± 1.4 vs. -0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively,
= 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively,
< 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and -36 ± 104 mmol/L, respectively,
< 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Androgens - blood</subject><subject>Anthropometry</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>blood serum</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Diet</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fiber - administration & dosage</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Globulins</subject><subject>Hirsutism</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Metabolism</subject><subject>Metabolome</subject><subject>Nutrition Assessment</subject><subject>Oxidative Stress - drug effects</subject><subject>patients</subject><subject>placebos</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - drug therapy</subject><subject>sex hormone-binding globulin</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>sex reversal</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - blood</subject><subject>women</subject><subject>Young Adult</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkd9qFDEUxoMottRe-AIS8EYvRvNnJpncCNKttVDpYqu34cxsYlMyyZpkWvYhfOdm2bpUQyA5Ob_v4wsHodeUfOBckY9hVpRR1pNn6JARyRohWv78yf0AHed8S7ZLEin4S3TAFO2F7NQh-nNqrRkLjhZf30e8cLVMJhS8iNnk7fNPV2ByAS_w1bxeezPVLhQXA677mykwRO9GvEzROr-TnIc8exea7ya7XKC6Laui6jK-d-UGL6PfjJtcquzyDtIGX23CKsXJvEIvLPhsjh_PI_Tjy-n1ydfm4vLs_OTzRTO2XJRGMCFIq8hoV8OwIkBa4B0oAS3tGB0IGSwlwIFSBUCgY20vlZVD2wmjasWP0Ked73oeJrMaa7QEXq-Tm2ocHcHpfzvB3ehf8U53slpxWg3ePRqk-Hs2uejJ5dF4D8HEOWvGeqG4FKqr6Nv_0Ns4p1C_p6nq-65XUolKvd9RY4o5J2P3YSjR2znr_Zwr--Zp-j35d6r8ARWfpL4</recordid><startdate>20171124</startdate><enddate>20171124</enddate><creator>Jamilian, Mehri</creator><creator>Foroozanfard, Fatemeh</creator><creator>Rahmani, Elham</creator><creator>Talebi, Maesoomeh</creator><creator>Bahmani, Fereshteh</creator><creator>Asemi, Zatollah</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5265-4792</orcidid></search><sort><creationdate>20171124</creationdate><title>Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome</title><author>Jamilian, Mehri ; Foroozanfard, Fatemeh ; Rahmani, Elham ; Talebi, Maesoomeh ; Bahmani, Fereshteh ; Asemi, Zatollah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-62660490cfdbbd0a04a35a96a41521b00bf10a3a119aa0a524879f7b456e95243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Androgens - blood</topic><topic>Anthropometry</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>blood serum</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Diet</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fiber - administration & dosage</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Dietary Supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Globulins</topic><topic>Hirsutism</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Metabolism</topic><topic>Metabolome</topic><topic>Nutrition Assessment</topic><topic>Oxidative Stress - drug effects</topic><topic>patients</topic><topic>placebos</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - drug therapy</topic><topic>sex hormone-binding globulin</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>sex reversal</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - blood</topic><topic>women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jamilian, Mehri</creatorcontrib><creatorcontrib>Foroozanfard, Fatemeh</creatorcontrib><creatorcontrib>Rahmani, Elham</creatorcontrib><creatorcontrib>Talebi, Maesoomeh</creatorcontrib><creatorcontrib>Bahmani, Fereshteh</creatorcontrib><creatorcontrib>Asemi, Zatollah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jamilian, Mehri</au><au>Foroozanfard, Fatemeh</au><au>Rahmani, Elham</au><au>Talebi, Maesoomeh</au><au>Bahmani, Fereshteh</au><au>Asemi, Zatollah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2017-11-24</date><risdate>2017</risdate><volume>9</volume><issue>12</issue><spage>1280</spage><pages>1280-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (
= 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (-0.2 ± 0.2 vs. -0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively,
= 0.02), free androgen index (FAI) (-0.06 ± 0.12 vs. -0.02 ± 0.12 and +0.004 ± 0.04, respectively,
= 0.04), hirsutism (-1.1 ± 1.1 vs. -0.8 ± 1.2 and -0.1 ± 0.4, respectively,
= 0.001) and high-sensitivity C-reactive protein (hs-CRP) (-0.7 ± 1.4 vs. -0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively,
= 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively,
< 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and -36 ± 104 mmol/L, respectively,
< 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29186759</pmid><doi>10.3390/nu9121280</doi><orcidid>https://orcid.org/0000-0001-5265-4792</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Adolescent Adult Androgens - blood Anthropometry antioxidant activity Antioxidants Biomarkers - blood Blood Glucose - metabolism blood serum C-reactive protein C-Reactive Protein - metabolism Diet Dietary Carbohydrates - administration & dosage Dietary Fats - administration & dosage Dietary Fiber - administration & dosage Dietary Proteins - administration & dosage Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Female Globulins Hirsutism Humans Insulin Insulin Resistance Metabolism Metabolome Nutrition Assessment Oxidative Stress - drug effects patients placebos Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - drug therapy sex hormone-binding globulin Sex Hormone-Binding Globulin - metabolism sex reversal Testosterone Testosterone - blood Vitamin D Vitamin D - administration & dosage Vitamin D - blood women Young Adult |
| title | Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome |
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