Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age Study
Subclinical micronutrient deficiency in older adults is associated with chronic age-related diseases and adverse functional outcomes. In Germany, the older population is at risk of insufficient micronutrient intake, but representative studies on micronutrient status in old and very old adults are sc...
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| Veröffentlicht in: | Nutrients 2017-11, Vol.9 (12), p.1276 |
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| creator | Conzade, Romy Koenig, Wolfgang Heier, Margit Schneider, Andrea Grill, Eva Peters, Annette Thorand, Barbara |
| description | Subclinical micronutrient deficiency in older adults is associated with chronic age-related diseases and adverse functional outcomes. In Germany, the older population is at risk of insufficient micronutrient intake, but representative studies on micronutrient status in old and very old adults are scarce. This study's objectives were to estimate the prevalence of subclinical vitamin D, folate, vitamin B
and iron deficiencies among older adults, aged 65 to 93, from the KORA-Age study in Augsburg, Germany (
= 1079), and to examine associated predictors, using multiple logistic regression. Serum concentrations of 25-hydroxyvitamin D (25OHD), folate, vitamin B
, and iron were analyzed. The prevalence of subclinical vitamin D and vitamin B
deficiencies were high, with 52.0% and 27.3% of individuals having low 25OHD ( |
| doi_str_mv | 10.3390/nu9121276 |
| format | Article |
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and iron deficiencies among older adults, aged 65 to 93, from the KORA-Age study in Augsburg, Germany (
= 1079), and to examine associated predictors, using multiple logistic regression. Serum concentrations of 25-hydroxyvitamin D (25OHD), folate, vitamin B
, and iron were analyzed. The prevalence of subclinical vitamin D and vitamin B
deficiencies were high, with 52.0% and 27.3% of individuals having low 25OHD (<50 nmol/L) and low vitamin B
concentrations (<221 pmol/L), respectively. Furthermore, 11.0% had low iron (men <11.6 µmol/L, women <9.0 µmol/L) and 8.7% had low folate levels (<13.6 nmol/L). Common predictors associated with subclinical micronutrient deficiency included very old age, physical inactivity, frailty and no/irregular use of supplements. Subclinical micronutrient deficiency is a public health concern among KORA-Age participants, especially for vitamins D and B
. The predictors identified provide further rationale for screening high-risk subgroups and developing targeted public health interventions to tackle prevailing micronutrient inadequacies among older adults.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu9121276</identifier><identifier>PMID: 29168737</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>25-Hydroxyvitamin D ; Adults ; Age ; blood serum ; Cyanocobalamin ; elderly ; Folic acid ; Germany ; Iron ; men ; nutrient deficiencies ; Older people ; Physical activity ; Population studies ; Population-based studies ; Public health ; regression analysis ; Risk groups ; screening ; Subgroups ; Vitamin B ; Vitamin B12 ; Vitamin D ; Vitamins ; women</subject><ispartof>Nutrients, 2017-11, Vol.9 (12), p.1276</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-17d3abb4ae52c452bc5a172330398db6e419e15385c2583692d67a66453163b93</citedby><cites>FETCH-LOGICAL-c436t-17d3abb4ae52c452bc5a172330398db6e419e15385c2583692d67a66453163b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748727/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748727/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29168737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conzade, Romy</creatorcontrib><creatorcontrib>Koenig, Wolfgang</creatorcontrib><creatorcontrib>Heier, Margit</creatorcontrib><creatorcontrib>Schneider, Andrea</creatorcontrib><creatorcontrib>Grill, Eva</creatorcontrib><creatorcontrib>Peters, Annette</creatorcontrib><creatorcontrib>Thorand, Barbara</creatorcontrib><title>Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age Study</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Subclinical micronutrient deficiency in older adults is associated with chronic age-related diseases and adverse functional outcomes. In Germany, the older population is at risk of insufficient micronutrient intake, but representative studies on micronutrient status in old and very old adults are scarce. This study's objectives were to estimate the prevalence of subclinical vitamin D, folate, vitamin B
and iron deficiencies among older adults, aged 65 to 93, from the KORA-Age study in Augsburg, Germany (
= 1079), and to examine associated predictors, using multiple logistic regression. Serum concentrations of 25-hydroxyvitamin D (25OHD), folate, vitamin B
, and iron were analyzed. The prevalence of subclinical vitamin D and vitamin B
deficiencies were high, with 52.0% and 27.3% of individuals having low 25OHD (<50 nmol/L) and low vitamin B
concentrations (<221 pmol/L), respectively. Furthermore, 11.0% had low iron (men <11.6 µmol/L, women <9.0 µmol/L) and 8.7% had low folate levels (<13.6 nmol/L). Common predictors associated with subclinical micronutrient deficiency included very old age, physical inactivity, frailty and no/irregular use of supplements. Subclinical micronutrient deficiency is a public health concern among KORA-Age participants, especially for vitamins D and B
. The predictors identified provide further rationale for screening high-risk subgroups and developing targeted public health interventions to tackle prevailing micronutrient inadequacies among older adults.</description><subject>25-Hydroxyvitamin D</subject><subject>Adults</subject><subject>Age</subject><subject>blood serum</subject><subject>Cyanocobalamin</subject><subject>elderly</subject><subject>Folic acid</subject><subject>Germany</subject><subject>Iron</subject><subject>men</subject><subject>nutrient deficiencies</subject><subject>Older people</subject><subject>Physical activity</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Public health</subject><subject>regression analysis</subject><subject>Risk groups</subject><subject>screening</subject><subject>Subgroups</subject><subject>Vitamin B</subject><subject>Vitamin B12</subject><subject>Vitamin D</subject><subject>Vitamins</subject><subject>women</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkk1PFTEUhidGIgRY-AdMEze6GJ22M_1wYXJFRCLmEtD1pNOegZJOe2mnJPcv-KvpDXiDbDyb8zZ98uZ8VdVr3HygVDYffZaYYMLZi2qPNJzUjLX05RO9Wx2mdNNsgjec0VfVLpGYCU75XvXnPMKdcuA1IOUNKk9j9RxiQmFEl3nQznqrlUM_rY7B5zla8DP6CqPVRek1sh6dQJyUR0tnIKKFyW5On9AFpI1AYwwTmq8BnYdVdmq2wddfVAKDfiwvFvXiCtDlnM36oNoZlUtw-Jj3q9_fjn8dfa_PlienR4uzWreUzTXmhqphaBV0RLcdGXSnMCeUNlQKMzBosQTcUdFp0gnKJDGMqzKIjmJGB0n3q88Pvqs8TGB0aScq16-inVRc90HZ_t8fb6_7q3DXd7wVnPBi8O7RIIbbDGnuJ5s0OKc8hJx6QgSTLRNN-18US8YFazjFBX37DL0JOfoyiUIJ0Ukq-IZ6_0CVZaQUYdzWjZt-cw_99h4K--Zpo1vy7_bpPYfXsBo</recordid><startdate>20171123</startdate><enddate>20171123</enddate><creator>Conzade, Romy</creator><creator>Koenig, Wolfgang</creator><creator>Heier, Margit</creator><creator>Schneider, Andrea</creator><creator>Grill, Eva</creator><creator>Peters, Annette</creator><creator>Thorand, Barbara</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20171123</creationdate><title>Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age Study</title><author>Conzade, Romy ; Koenig, Wolfgang ; Heier, Margit ; Schneider, Andrea ; Grill, Eva ; Peters, Annette ; Thorand, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-17d3abb4ae52c452bc5a172330398db6e419e15385c2583692d67a66453163b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adults</topic><topic>Age</topic><topic>blood serum</topic><topic>Cyanocobalamin</topic><topic>elderly</topic><topic>Folic acid</topic><topic>Germany</topic><topic>Iron</topic><topic>men</topic><topic>nutrient deficiencies</topic><topic>Older people</topic><topic>Physical activity</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Public health</topic><topic>regression analysis</topic><topic>Risk groups</topic><topic>screening</topic><topic>Subgroups</topic><topic>Vitamin B</topic><topic>Vitamin B12</topic><topic>Vitamin D</topic><topic>Vitamins</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conzade, Romy</creatorcontrib><creatorcontrib>Koenig, Wolfgang</creatorcontrib><creatorcontrib>Heier, Margit</creatorcontrib><creatorcontrib>Schneider, Andrea</creatorcontrib><creatorcontrib>Grill, Eva</creatorcontrib><creatorcontrib>Peters, Annette</creatorcontrib><creatorcontrib>Thorand, Barbara</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conzade, Romy</au><au>Koenig, Wolfgang</au><au>Heier, Margit</au><au>Schneider, Andrea</au><au>Grill, Eva</au><au>Peters, Annette</au><au>Thorand, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age Study</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2017-11-23</date><risdate>2017</risdate><volume>9</volume><issue>12</issue><spage>1276</spage><pages>1276-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Subclinical micronutrient deficiency in older adults is associated with chronic age-related diseases and adverse functional outcomes. In Germany, the older population is at risk of insufficient micronutrient intake, but representative studies on micronutrient status in old and very old adults are scarce. This study's objectives were to estimate the prevalence of subclinical vitamin D, folate, vitamin B
and iron deficiencies among older adults, aged 65 to 93, from the KORA-Age study in Augsburg, Germany (
= 1079), and to examine associated predictors, using multiple logistic regression. Serum concentrations of 25-hydroxyvitamin D (25OHD), folate, vitamin B
, and iron were analyzed. The prevalence of subclinical vitamin D and vitamin B
deficiencies were high, with 52.0% and 27.3% of individuals having low 25OHD (<50 nmol/L) and low vitamin B
concentrations (<221 pmol/L), respectively. Furthermore, 11.0% had low iron (men <11.6 µmol/L, women <9.0 µmol/L) and 8.7% had low folate levels (<13.6 nmol/L). Common predictors associated with subclinical micronutrient deficiency included very old age, physical inactivity, frailty and no/irregular use of supplements. Subclinical micronutrient deficiency is a public health concern among KORA-Age participants, especially for vitamins D and B
. The predictors identified provide further rationale for screening high-risk subgroups and developing targeted public health interventions to tackle prevailing micronutrient inadequacies among older adults.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29168737</pmid><doi>10.3390/nu9121276</doi><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | 25-Hydroxyvitamin D Adults Age blood serum Cyanocobalamin elderly Folic acid Germany Iron men nutrient deficiencies Older people Physical activity Population studies Population-based studies Public health regression analysis Risk groups screening Subgroups Vitamin B Vitamin B12 Vitamin D Vitamins women |
| title | Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age Study |
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