Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress

A systems-level understanding of cytokine-mediated, intertissue signaling is one of the keys to developing fundamental insight into the links between aging and inflammation. Here, we employed Drosophila, a routine model for analysis of cytokine signaling pathways in higher animals, to identify a rec...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-12, Vol.114 (52), p.13786-13791
Hauptverfasser:	Sung, Eui Jae, Ryuda, Masasuke, Matsumoto, Hitoshi, Uryu, Outa, Ochiai, Masanori, Cook, Molly E., Yi, Na Young, Wang, Huanchen, Putney, James W., Bird, Gary S., Shears, Stephen B., Hayakawa, Yoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Antimicrobial peptides Biological Sciences Calcium Calcium signalling Cytokines Double-stranded RNA Drosophila Environmental stress Fitness Homeostasis Immune response Immunology Innate immunity Insects Insulin Interrogation Larvae Life span Low temperature Peptides Phospholipase Phospholipase C Proteins Signal transduction
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