Impact of Her-2 Overexpression on Survival of Patients with Metastatic Breast Cancer
Introduction: Breast cancer is a complex and heterogeneous disease which is increasingly important as a public health problem. In Brazil, 57,960 new cases have been estimated to be the burden in 2016 and 2017. Despite advances in early diagnosis and therapy, approximately 20-30% of patients, even wi...
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| Veröffentlicht in: | Asian Pacific journal of cancer prevention : APJCP 2017-10, Vol.18 (10), p.2673-2678 |
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| container_title | Asian Pacific journal of cancer prevention : APJCP |
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| creator | dos Santos, Giovana Tavares Camillo, Natália Dressler Berto, Maiquidieli Dal Prolla, João Carlos da Cruz, Ivana Beatrice Mânica Roehe, Adriana Vial Brackmann, Rosicler Luzia Reiter, Keli Critine Bica, Claudia Giuliano |
| description | Introduction: Breast cancer is a complex and heterogeneous disease which is increasingly important as a public
health problem. In Brazil, 57,960 new cases have been estimated to be the burden in 2016 and 2017. Despite advances
in early diagnosis and therapy, approximately 20-30% of patients, even with early stage lesions, will develop distant
metastatic disease. Tumors with similar clinical and pathological presentations may have differing behavior, so it
is important to understand specific biological characteristics. Objective: To investigate tumor markers of primary
tumors featuring pleural metastasis to identify organ-specific characteristics of metastatic breast cancer. Methods:
In a historical cohort study, immunohistochemistry was performed on cell blocks of neoplastic pleural effusions and
results were compared with clinicopathological data. Results: The median survival time with Her-2 overexpression
in malignant pleural effusions was 2.2 months, whereas cases without overexpression survived, on average, for seven
months (p = 0.02). Conclusions: We emphasize that metastases may behave independently of primary tumors, but the
present results indicate that therapeutic agents targeting Her-2 overexpression could increase survival in metastatic
breast cancer cases. |
| doi_str_mv | 10.22034/APJCP.2017.18.10.2673 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5747388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>29072390</sourcerecordid><originalsourceid>FETCH-LOGICAL-p148t-63143d251485885cbf89731f5fc5a913cdeee8f080768a96e2bff3d04563fa903</originalsourceid><addsrcrecordid>eNpVkG1LwzAQx4Mobk6_wsgXaM1D89A3wizqJpMNnOC7krWJi2xtSbKq394MH1A4uLv_3f24OwDGGKWEIJpdTpb3xTIlCIsUy_Qgc0GPwJBkgieCk-djMMQM00RQLgfgzPtXhDImBTsFA5IjQWiOhmA123WqCrA1cKpdQuCi106_d057b9sGRnvcu972anvoWapgdRM8fLNhAx90UD5EqYLXTscQFqqptDsHJ0Ztvb749iPwdHuzKqbJfHE3KybzpMOZDAmnOKM1YTFhUrJqbWQuKDbMVEzlmFa11loaJJHgUuVck7UxtI5XcGpUjugIXH1xu_16p-sqbubUtuyc3Sn3UbbKlv8rjd2UL21fMpEJKmUEjP8Cfid__kM_AW36ao4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Impact of Her-2 Overexpression on Survival of Patients with Metastatic Breast Cancer</title><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>Free E- Journals</source><source>EZB Electronic Journals Library</source><creator>dos Santos, Giovana Tavares ; Camillo, Natália Dressler ; Berto, Maiquidieli Dal ; Prolla, João Carlos ; da Cruz, Ivana Beatrice Mânica ; Roehe, Adriana Vial ; Brackmann, Rosicler Luzia ; Reiter, Keli Critine ; Bica, Claudia Giuliano</creator><creatorcontrib>dos Santos, Giovana Tavares ; Camillo, Natália Dressler ; Berto, Maiquidieli Dal ; Prolla, João Carlos ; da Cruz, Ivana Beatrice Mânica ; Roehe, Adriana Vial ; Brackmann, Rosicler Luzia ; Reiter, Keli Critine ; Bica, Claudia Giuliano</creatorcontrib><description>Introduction: Breast cancer is a complex and heterogeneous disease which is increasingly important as a public
health problem. In Brazil, 57,960 new cases have been estimated to be the burden in 2016 and 2017. Despite advances
in early diagnosis and therapy, approximately 20-30% of patients, even with early stage lesions, will develop distant
metastatic disease. Tumors with similar clinical and pathological presentations may have differing behavior, so it
is important to understand specific biological characteristics. Objective: To investigate tumor markers of primary
tumors featuring pleural metastasis to identify organ-specific characteristics of metastatic breast cancer. Methods:
In a historical cohort study, immunohistochemistry was performed on cell blocks of neoplastic pleural effusions and
results were compared with clinicopathological data. Results: The median survival time with Her-2 overexpression
in malignant pleural effusions was 2.2 months, whereas cases without overexpression survived, on average, for seven
months (p = 0.02). Conclusions: We emphasize that metastases may behave independently of primary tumors, but the
present results indicate that therapeutic agents targeting Her-2 overexpression could increase survival in metastatic
breast cancer cases.</description><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.22034/APJCP.2017.18.10.2673</identifier><identifier>PMID: 29072390</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><ispartof>Asian Pacific journal of cancer prevention : APJCP, 2017-10, Vol.18 (10), p.2673-2678</ispartof><rights>Creative Commons Attribution License</rights><rights>Copyright: © Asian Pacific Journal of Cancer Prevention 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747388/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747388/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29072390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>dos Santos, Giovana Tavares</creatorcontrib><creatorcontrib>Camillo, Natália Dressler</creatorcontrib><creatorcontrib>Berto, Maiquidieli Dal</creatorcontrib><creatorcontrib>Prolla, João Carlos</creatorcontrib><creatorcontrib>da Cruz, Ivana Beatrice Mânica</creatorcontrib><creatorcontrib>Roehe, Adriana Vial</creatorcontrib><creatorcontrib>Brackmann, Rosicler Luzia</creatorcontrib><creatorcontrib>Reiter, Keli Critine</creatorcontrib><creatorcontrib>Bica, Claudia Giuliano</creatorcontrib><title>Impact of Her-2 Overexpression on Survival of Patients with Metastatic Breast Cancer</title><title>Asian Pacific journal of cancer prevention : APJCP</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>Introduction: Breast cancer is a complex and heterogeneous disease which is increasingly important as a public
health problem. In Brazil, 57,960 new cases have been estimated to be the burden in 2016 and 2017. Despite advances
in early diagnosis and therapy, approximately 20-30% of patients, even with early stage lesions, will develop distant
metastatic disease. Tumors with similar clinical and pathological presentations may have differing behavior, so it
is important to understand specific biological characteristics. Objective: To investigate tumor markers of primary
tumors featuring pleural metastasis to identify organ-specific characteristics of metastatic breast cancer. Methods:
In a historical cohort study, immunohistochemistry was performed on cell blocks of neoplastic pleural effusions and
results were compared with clinicopathological data. Results: The median survival time with Her-2 overexpression
in malignant pleural effusions was 2.2 months, whereas cases without overexpression survived, on average, for seven
months (p = 0.02). Conclusions: We emphasize that metastases may behave independently of primary tumors, but the
present results indicate that therapeutic agents targeting Her-2 overexpression could increase survival in metastatic
breast cancer cases.</description><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkG1LwzAQx4Mobk6_wsgXaM1D89A3wizqJpMNnOC7krWJi2xtSbKq394MH1A4uLv_3f24OwDGGKWEIJpdTpb3xTIlCIsUy_Qgc0GPwJBkgieCk-djMMQM00RQLgfgzPtXhDImBTsFA5IjQWiOhmA123WqCrA1cKpdQuCi106_d057b9sGRnvcu972anvoWapgdRM8fLNhAx90UD5EqYLXTscQFqqptDsHJ0Ztvb749iPwdHuzKqbJfHE3KybzpMOZDAmnOKM1YTFhUrJqbWQuKDbMVEzlmFa11loaJJHgUuVck7UxtI5XcGpUjugIXH1xu_16p-sqbubUtuyc3Sn3UbbKlv8rjd2UL21fMpEJKmUEjP8Cfid__kM_AW36ao4</recordid><startdate>20171026</startdate><enddate>20171026</enddate><creator>dos Santos, Giovana Tavares</creator><creator>Camillo, Natália Dressler</creator><creator>Berto, Maiquidieli Dal</creator><creator>Prolla, João Carlos</creator><creator>da Cruz, Ivana Beatrice Mânica</creator><creator>Roehe, Adriana Vial</creator><creator>Brackmann, Rosicler Luzia</creator><creator>Reiter, Keli Critine</creator><creator>Bica, Claudia Giuliano</creator><general>West Asia Organization for Cancer Prevention</general><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20171026</creationdate><title>Impact of Her-2 Overexpression on Survival of Patients with Metastatic Breast Cancer</title><author>dos Santos, Giovana Tavares ; Camillo, Natália Dressler ; Berto, Maiquidieli Dal ; Prolla, João Carlos ; da Cruz, Ivana Beatrice Mânica ; Roehe, Adriana Vial ; Brackmann, Rosicler Luzia ; Reiter, Keli Critine ; Bica, Claudia Giuliano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p148t-63143d251485885cbf89731f5fc5a913cdeee8f080768a96e2bff3d04563fa903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>dos Santos, Giovana Tavares</creatorcontrib><creatorcontrib>Camillo, Natália Dressler</creatorcontrib><creatorcontrib>Berto, Maiquidieli Dal</creatorcontrib><creatorcontrib>Prolla, João Carlos</creatorcontrib><creatorcontrib>da Cruz, Ivana Beatrice Mânica</creatorcontrib><creatorcontrib>Roehe, Adriana Vial</creatorcontrib><creatorcontrib>Brackmann, Rosicler Luzia</creatorcontrib><creatorcontrib>Reiter, Keli Critine</creatorcontrib><creatorcontrib>Bica, Claudia Giuliano</creatorcontrib><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>dos Santos, Giovana Tavares</au><au>Camillo, Natália Dressler</au><au>Berto, Maiquidieli Dal</au><au>Prolla, João Carlos</au><au>da Cruz, Ivana Beatrice Mânica</au><au>Roehe, Adriana Vial</au><au>Brackmann, Rosicler Luzia</au><au>Reiter, Keli Critine</au><au>Bica, Claudia Giuliano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Her-2 Overexpression on Survival of Patients with Metastatic Breast Cancer</atitle><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2017-10-26</date><risdate>2017</risdate><volume>18</volume><issue>10</issue><spage>2673</spage><epage>2678</epage><pages>2673-2678</pages><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>Introduction: Breast cancer is a complex and heterogeneous disease which is increasingly important as a public
health problem. In Brazil, 57,960 new cases have been estimated to be the burden in 2016 and 2017. Despite advances
in early diagnosis and therapy, approximately 20-30% of patients, even with early stage lesions, will develop distant
metastatic disease. Tumors with similar clinical and pathological presentations may have differing behavior, so it
is important to understand specific biological characteristics. Objective: To investigate tumor markers of primary
tumors featuring pleural metastasis to identify organ-specific characteristics of metastatic breast cancer. Methods:
In a historical cohort study, immunohistochemistry was performed on cell blocks of neoplastic pleural effusions and
results were compared with clinicopathological data. Results: The median survival time with Her-2 overexpression
in malignant pleural effusions was 2.2 months, whereas cases without overexpression survived, on average, for seven
months (p = 0.02). Conclusions: We emphasize that metastases may behave independently of primary tumors, but the
present results indicate that therapeutic agents targeting Her-2 overexpression could increase survival in metastatic
breast cancer cases.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>29072390</pmid><doi>10.22034/APJCP.2017.18.10.2673</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| title | Impact of Her-2 Overexpression on Survival of Patients with Metastatic Breast Cancer |
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