Tobacco and alcohol as risk factors for pancreatic cancer
Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population,...
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| Veröffentlicht in: | Baillière's best practice & research. Clinical gastroenterology 2017-10, Vol.31 (5), p.529-536 |
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| container_title | Baillière's best practice & research. Clinical gastroenterology |
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| creator | Korc, Murray Jeon, Christie Y. Edderkaoui, Mouad Pandol, Stephen J. Petrov, Maxim S. |
| description | Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of immune microenvironment in pancreatic carcinogenesis activated by tobacco and alcohol. |
| doi_str_mv | 10.1016/j.bpg.2017.09.001 |
| format | Article |
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The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of immune microenvironment in pancreatic carcinogenesis activated by tobacco and alcohol.</description><identifier>ISSN: 1521-6918</identifier><identifier>EISSN: 1532-1916</identifier><identifier>DOI: 10.1016/j.bpg.2017.09.001</identifier><identifier>PMID: 29195672</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Alcohol ; Alcohol Drinking - adverse effects ; Animals ; Bias ; Diabetes ; Disease Models, Animal ; Female ; Gastroenterology ; Genetically engineered mouse models ; Health risk assessment ; Humans ; Male ; Medical prognosis ; Meta-analysis ; Metabolism ; Mice ; Middle Aged ; Pancreatic cancer ; Pancreatic Neoplasms - etiology ; Pancreatic Neoplasms - pathology ; Pancreatitis ; Population ; Population risk ; Risk Factors ; Smoking ; Smoking - adverse effects ; Studies ; Tobacco</subject><ispartof>Baillière's best practice & research. Clinical gastroenterology, 2017-10, Vol.31 (5), p.529-536</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 1, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-87a596a1ea5e855edad74ef2dd70582e241cba15ad4acfcaeaac122e98cb060a3</citedby><cites>FETCH-LOGICAL-c545t-87a596a1ea5e855edad74ef2dd70582e241cba15ad4acfcaeaac122e98cb060a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521691817300963$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29195672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Korc, Murray</creatorcontrib><creatorcontrib>Jeon, Christie Y.</creatorcontrib><creatorcontrib>Edderkaoui, Mouad</creatorcontrib><creatorcontrib>Pandol, Stephen J.</creatorcontrib><creatorcontrib>Petrov, Maxim S.</creatorcontrib><creatorcontrib>on behalf of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)</creatorcontrib><creatorcontrib>Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)</creatorcontrib><title>Tobacco and alcohol as risk factors for pancreatic cancer</title><title>Baillière's best practice & research. Clinical gastroenterology</title><addtitle>Best Pract Res Clin Gastroenterol</addtitle><description>Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. 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| identifier | ISSN: 1521-6918 |
| ispartof | Baillière's best practice & research. Clinical gastroenterology, 2017-10, Vol.31 (5), p.529-536 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alcohol Alcohol Drinking - adverse effects Animals Bias Diabetes Disease Models, Animal Female Gastroenterology Genetically engineered mouse models Health risk assessment Humans Male Medical prognosis Meta-analysis Metabolism Mice Middle Aged Pancreatic cancer Pancreatic Neoplasms - etiology Pancreatic Neoplasms - pathology Pancreatitis Population Population risk Risk Factors Smoking Smoking - adverse effects Studies Tobacco |
| title | Tobacco and alcohol as risk factors for pancreatic cancer |
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