Inhalation of Fine Particulate Matter Impairs Endothelial Progenitor Cell Function Via Pulmonary Oxidative Stress

Exposure to fine particulate matter (PM ) air pollution is associated with the depletion of circulating endothelial progenitor cells (EPCs), as well as vascular injury and dysfunction. Nevertheless, it remains unclear whether PM exposure leads to significant impairments in EPC function. Hence, we st...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-01, Vol.38 (1), p.131-142
Hauptverfasser:	Haberzettl, Petra, Conklin, Daniel J, Abplanalp, Wesley T, Bhatnagar, Aruni, O'Toole, Timothy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Disease Models, Animal Endothelial Progenitor Cells - drug effects Endothelial Progenitor Cells - metabolism Endothelial Progenitor Cells - pathology Endothelial Progenitor Cells - transplantation Hindlimb Inhalation Exposure - adverse effects Ischemia - metabolism Ischemia - pathology Ischemia - physiopathology Ischemia - surgery Lung - drug effects Lung - metabolism Lung - pathology Male Mice, Inbred C57BL Mice, Transgenic Muscle, Skeletal - blood supply Neovascularization, Physiologic - drug effects Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Oxidative Stress - drug effects Particle Size Particulate Matter - toxicity Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Vascular Endothelial Growth Factor A - pharmacology
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