Modulation of Multidrug Resistance Gene Expression by Coumarin Derivatives in Human Leukemic Cells

The presence of multidrug resistance (MDR) in tumor cells is considered as the major cause of failure of cancer chemotherapy. The mechanism responsible for the phenomenon of multidrug resistance is explained, among others, as overexpression of membrane transporters primarily from the ABC family whic...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-13
Hauptverfasser:	Kocki, Janusz, Cioch, Maria, Kaczmarczyk, Robert, Galkowski, Dariusz, Bogucki, Jacek, Załuski, Daniel, Komsta, Łukasz, Bogucka-Kocka, Anna, Kubrak, Tomasz, Feldo, Marcin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular biology Chemotherapy Coumarins - pharmacology Drug resistance Drug Resistance, Neoplasm - drug effects Gene expression Gene Expression Regulation, Leukemic - drug effects HL-60 Cells Humans Leukemia Leukemia - drug therapy Leukemia - metabolism Multidrug resistant organisms Neoplasm Proteins - biosynthesis Tumors
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