Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax

Sampling of mucosal antigens regulates immune responses but may also promote dissemination of mucosal pathogens. Lung dendritic cells (LDCs) capture antigens and traffic them to lung-draining lymph nodes (LDLNs) dependent on the chemokine receptor CCR7 (chemokine (C-C motif) receptor 7). LDCs also c...

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Veröffentlicht in:	Mucosal immunology 2012-07, Vol.5 (4), p.444-454
Hauptverfasser:	Rayamajhi, M, Delgado, C, Condon, T V, Riches, D W, Lenz, L L
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/40 631/250/2504/133 631/250/347 692/699/255/1318 Allergology Animals Anthrax - immunology Anthrax - microbiology Anthrax - mortality Antibodies B-Lymphocytes - immunology B-Lymphocytes - metabolism Bacillus anthracis - immunology Biomedical and Life Sciences Biomedicine Cell Line Dendritic Cells - immunology Dendritic Cells - metabolism Disease Models, Animal Gastroenterology Immunoglobulin M - immunology Immunoglobulin M - metabolism Immunology Lung - immunology Lung - microbiology Lymph Nodes - immunology Lymph Nodes - metabolism Lymphocyte Depletion Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Receptors, Antigen, B-Cell - immunology Receptors, Antigen, B-Cell - metabolism Receptors, CCR7 - immunology Receptors, CCR7 - metabolism Receptors, Complement - immunology Receptors, Complement - metabolism Spores, Bacterial - immunology
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