Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs). We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo protects against neurodegeneration and prolongs survival in transgenic P301S Tau mice. Biochemical fractionation shows co-...

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Veröffentlicht in:	Nature neuroscience 2018-01, Vol.21 (1), p.72-80
Hauptverfasser:	Apicco, Daniel J., Ash, Peter E. A., Maziuk, Brandon, LeBlang, Chelsey, Medalla, Maria, Al Abdullatif, Ali, Ferragud, Antonio, Botelho, Emily, Ballance, Heather I., Dhawan, Uma, Boudeau, Samantha, Cruz, Anna Lourdes, Kashy, Daniel, Wong, Aria, Goldberg, Lisa R., Yazdani, Neema, Zhang, Cheng, Ung, Choong Y., Tripodis, Yorghos, Kanaan, Nicholas M., Ikezu, Tsuneya, Cottone, Pietro, Leszyk, John, Li, Hu, Luebke, Jennifer, Bryant, Camron D., Wolozin, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689 692/699/375/132/1283 Analysis Animal Genetics and Genomics Animals Animals, Newborn Antigens Behavioral Sciences Binding proteins Biochemistry Biocompatibility Biological Techniques Biomedical and Life Sciences Biomedicine Cognition Disorders - etiology Cognition Disorders - genetics Cytoplasm - metabolism Cytoplasm - pathology Cytoplasm - ultrastructure Disease Models, Animal Endoribonucleases - metabolism Female Fractionation Gene Expression Regulation - genetics Genetic engineering Granular materials In vivo methods and tests Life span Localization Locomotion - genetics Lymphocytes T Male Maze Learning - physiology Medical research Mice Mice, Inbred C57BL Mice, Transgenic Mutation - genetics Neurobiology Neurodegeneration Neurodegenerative diseases Neurofibrillary tangles Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Neurofibrillary Tangles - ultrastructure Neurons Neurons - pathology Neurons - ultrastructure Neurosciences Oligomers Pathological physiology Protein binding Proteins Ribonucleic acid RNA RNA-binding protein RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Survival Synapses - metabolism Synapses - ultrastructure T cells Tau protein tau Proteins - genetics tau Proteins - metabolism Tauopathies - genetics Tauopathies - metabolism Tauopathies - pathology Tauopathies - prevention & control TIA-1 protein Toxicity Trans-Activators - metabolism Transgenic mice
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