The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics

Kidney podocytes represent a key constituent of the glomerular filtration barrier. Identifying the molecular mechanisms of podocyte injury and survival is important for better understanding and management of kidney diseases. KIBRA (kidney brain protein), an upstream regulator of the Hippo signaling...

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Veröffentlicht in:	The Journal of biological chemistry 2017-12, Vol.292 (51), p.21137-21148
Hauptverfasser:	Meliambro, Kristin, Wong, Jenny S., Ray, Justina, Calizo, Rhodora C., Towne, Sara, Cole, Beatriz, El Salem, Fadi, Gordon, Ronald E., Kaufman, Lewis, He, John C., Azeloglu, Evren U., Campbell, Kirk N.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actin Cytoskeleton - metabolism Adaptor Proteins, Signal Transducing - metabolism Animals Biopsy Female focal adhesion Gene Expression Regulation Glomerulosclerosis, Focal Segmental - enzymology Glomerulosclerosis, Focal Segmental - metabolism Glomerulosclerosis, Focal Segmental - pathology HEK293 Cells Hippo pathway Humans Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Male Mice, Inbred C57BL Mice, Knockout Microscopy, Electron, Scanning Microscopy, Electron, Transmission Molecular Bases of Disease Phosphoproteins - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation podocyte Podocytes - metabolism Podocytes - pathology Podocytes - ultrastructure Protein Processing, Post-Translational Protein-Serine-Threonine Kinases - metabolism RNA Interference Serine - metabolism Signal Transduction Transcription Factors yes-associated protein (YAP)
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