Heparanase Overexpresses in Keratoconic Cornea and Tears Depending on the Pathologic Grade

Background. Keratoconus has classically been defined as a noninflammatory disorder, although recent studies show elevated levels of inflammatory markers suggesting that keratoconus could be, at least in part, an inflammatory condition. Heparanase upregulation has been described in multiple inflammat...

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Veröffentlicht in:	Disease markers 2017-01, Vol.2017 (2017), p.1-7
Hauptverfasser:	Quirós, Luis M., Vazquez, Fernando, Lisa, Carlos, González, Javier, Alcalde, Ignacio, Ferrara, Guilherme, Merayo-Lloves, Jesús, García-Suárez, Olivia, García, Beatriz, Alfonso, Jose F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological markers Biomarkers Biomarkers - metabolism Catalysis Catalytic activity Cells, Cultured Control methods Cornea Cornea - enzymology Cornea - metabolism Enzymatic activity Epithelial cells Gene expression Genetic aspects Glucuronidase - genetics Glucuronidase - metabolism Heparan sulfate Heparitin Sulfate - metabolism Humans Immunohistochemistry Inflammatory diseases Keratoconus Keratoconus - enzymology Keratoconus - metabolism Keratoconus - pathology Polymerase chain reaction Substrates Sulfates Tears Tears - enzymology Tears - metabolism Transcription Up-Regulation
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