Serum complexed and free prostate-specific antigen (PSA) for the diagnosis of the polycystic ovarian syndrome (PCOS)
Polycystic ovarian syndrome (PCOS) is a common cause of reproductive and metabolic dysfunction. We hypothesized that serum prostate-specific antigen (PSA) may constitute a new biomarker for hyperandrogenism in PCOS. We conducted a cross-sectional study of 45 women with PCOS and 40 controls. Serum fr...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2017-10, Vol.55 (11), p.1789-1797 |
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| creator | Diamandis, Eleftherios P. Stanczyk, Frank Z. Wheeler, Sarah Mathew, Anu Stengelin, Martin Nikolenko, Galina Glezer, Eli N. Brown, Marshall D. Zheng, Yingye Chen, Yen-Hao Wu, Hsiao-Li Azziz, Ricardo |
| description | Polycystic ovarian syndrome (PCOS) is a common cause of reproductive and metabolic dysfunction. We hypothesized that serum prostate-specific antigen (PSA) may constitute a new biomarker for hyperandrogenism in PCOS.
We conducted a cross-sectional study of 45 women with PCOS and 40 controls. Serum from these women was analyzed for androgenic steroids and for complexed PSA (cPSA) and free PSA (fPSA) with a novel fifth- generation assay with a sensitivity of ~10 fg/mL for cPSA and 140 fg/mL for fPSA.
cPSA and fPSA levels were about three times higher in PCOS compared to controls. However, in PCOS, cPSA and fPSA did not differ according to waist-to-hip ratio, Ferriman-Gallwey score, or degree of hyperandrogenemia or oligo-ovulation. In PCOS and control women, serum cPSA and fPSA levels were highly correlated with each other, and with free and total testosterone levels, but not with other hormones. Adjusting for age, body mass index (BMI) and race, cPSA was significantly associated with PCOS, with an odds ratio (OR) of 5.67 (95% confidence interval [CI]: 1.86, 22.0). The OR of PCOS for fPSA was 7.04 (95% CI: 1.65, 40.4). A multivariate model that included age, BMI, race and cPSA yielded an area-under-the-receiver-operating-characteristic curve of 0.89.
Serum cPSA and fPSA are novel biomarkers for hyperandrogenism in PCOS and may have value for disease diagnosis. |
| doi_str_mv | 10.1515/cclm-2016-1124 |
| format | Article |
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We conducted a cross-sectional study of 45 women with PCOS and 40 controls. Serum from these women was analyzed for androgenic steroids and for complexed PSA (cPSA) and free PSA (fPSA) with a novel fifth- generation assay with a sensitivity of ~10 fg/mL for cPSA and 140 fg/mL for fPSA.
cPSA and fPSA levels were about three times higher in PCOS compared to controls. However, in PCOS, cPSA and fPSA did not differ according to waist-to-hip ratio, Ferriman-Gallwey score, or degree of hyperandrogenemia or oligo-ovulation. In PCOS and control women, serum cPSA and fPSA levels were highly correlated with each other, and with free and total testosterone levels, but not with other hormones. Adjusting for age, body mass index (BMI) and race, cPSA was significantly associated with PCOS, with an odds ratio (OR) of 5.67 (95% confidence interval [CI]: 1.86, 22.0). The OR of PCOS for fPSA was 7.04 (95% CI: 1.65, 40.4). A multivariate model that included age, BMI, race and cPSA yielded an area-under-the-receiver-operating-characteristic curve of 0.89.
Serum cPSA and fPSA are novel biomarkers for hyperandrogenism in PCOS and may have value for disease diagnosis.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/cclm-2016-1124</identifier><identifier>PMID: 28361781</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Adult ; androgen-regulated genes ; Antigens ; Area Under Curve ; Biomarkers ; Biomarkers - blood ; Body mass ; Body Mass Index ; Confidence intervals ; Cross-Sectional Studies ; Diagnosis ; Female ; Hip ; hirsutism ; Hormones ; Humans ; hyperandrogenism ; Immunoassay ; Luminescent Measurements ; Multivariate Analysis ; Odds Ratio ; Ovulation ; polycystic ovarian syndrome ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - diagnosis ; Prostate ; Prostate-specific antigen ; Prostate-Specific Antigen - blood ; Reagent Kits, Diagnostic ; ROC Curve ; serum biomarkers ; Steroid hormones ; Steroids ; Testosterone ; urine biomarkers</subject><ispartof>Clinical chemistry and laboratory medicine, 2017-10, Vol.55 (11), p.1789-1797</ispartof><rights>Copyright Walter De Gruyter & Company 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-517da977a84c48e4a05c8be8883e1f07418756650740aa4ce601c83069d448423</citedby><cites>FETCH-LOGICAL-c521t-517da977a84c48e4a05c8be8883e1f07418756650740aa4ce601c83069d448423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2016-1124/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2016-1124/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,66754,68538</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28361781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diamandis, Eleftherios P.</creatorcontrib><creatorcontrib>Stanczyk, Frank Z.</creatorcontrib><creatorcontrib>Wheeler, Sarah</creatorcontrib><creatorcontrib>Mathew, Anu</creatorcontrib><creatorcontrib>Stengelin, Martin</creatorcontrib><creatorcontrib>Nikolenko, Galina</creatorcontrib><creatorcontrib>Glezer, Eli N.</creatorcontrib><creatorcontrib>Brown, Marshall D.</creatorcontrib><creatorcontrib>Zheng, Yingye</creatorcontrib><creatorcontrib>Chen, Yen-Hao</creatorcontrib><creatorcontrib>Wu, Hsiao-Li</creatorcontrib><creatorcontrib>Azziz, Ricardo</creatorcontrib><title>Serum complexed and free prostate-specific antigen (PSA) for the diagnosis of the polycystic ovarian syndrome (PCOS)</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description>Polycystic ovarian syndrome (PCOS) is a common cause of reproductive and metabolic dysfunction. We hypothesized that serum prostate-specific antigen (PSA) may constitute a new biomarker for hyperandrogenism in PCOS.
We conducted a cross-sectional study of 45 women with PCOS and 40 controls. Serum from these women was analyzed for androgenic steroids and for complexed PSA (cPSA) and free PSA (fPSA) with a novel fifth- generation assay with a sensitivity of ~10 fg/mL for cPSA and 140 fg/mL for fPSA.
cPSA and fPSA levels were about three times higher in PCOS compared to controls. However, in PCOS, cPSA and fPSA did not differ according to waist-to-hip ratio, Ferriman-Gallwey score, or degree of hyperandrogenemia or oligo-ovulation. In PCOS and control women, serum cPSA and fPSA levels were highly correlated with each other, and with free and total testosterone levels, but not with other hormones. Adjusting for age, body mass index (BMI) and race, cPSA was significantly associated with PCOS, with an odds ratio (OR) of 5.67 (95% confidence interval [CI]: 1.86, 22.0). The OR of PCOS for fPSA was 7.04 (95% CI: 1.65, 40.4). A multivariate model that included age, BMI, race and cPSA yielded an area-under-the-receiver-operating-characteristic curve of 0.89.
Serum cPSA and fPSA are novel biomarkers for hyperandrogenism in PCOS and may have value for disease diagnosis.</description><subject>Adult</subject><subject>androgen-regulated genes</subject><subject>Antigens</subject><subject>Area Under Curve</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Confidence intervals</subject><subject>Cross-Sectional Studies</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Hip</subject><subject>hirsutism</subject><subject>Hormones</subject><subject>Humans</subject><subject>hyperandrogenism</subject><subject>Immunoassay</subject><subject>Luminescent Measurements</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Ovulation</subject><subject>polycystic ovarian syndrome</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - diagnosis</subject><subject>Prostate</subject><subject>Prostate-specific antigen</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Reagent Kits, Diagnostic</subject><subject>ROC Curve</subject><subject>serum biomarkers</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>Testosterone</subject><subject>urine biomarkers</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUU1v1TAQjBCIltIrR2SJS3tI8cYf8bsgVU9AK1Uq0qNny3U2r66SONhOS_49Tr9BnDzyzs7u7BTFB6BHIEB8trbry4qCLAEq_qrYBc7qkjMGr-8wL6WsYKd4F-M1pSAEr98WO5ViEmoFu0XaYJh6Yn0_dvgbG2KGhrQBkYzBx2QSlnFE61pncym5LQ7k4Mfm-JC0PpB0haRxZjv46CLx7d3H6LvZzjHlDn9jgjMDifPQBN9jbl2fbw7fF29a00Xcf3j3iotvX3-uT8qz8--n6-Oz0ooKUimgbsyqro3ilivkhgqrLlEpxRBaWnNQtZBSZESN4RYlBasYlauGc8Urtld8udcdp8seG4tDCqbTY3C9CbP2xum_K4O70lt_o0XNK0plFjh4EAj-14Qx6d5Fi11nBvRT1JBXAQWSLbM-_UO99lMYsj0NK8GoqgSFzDq6Z9l83RiwfVoGqF4C1UugeglUL4Hmho8vLTzRHxN89nhruoShwW2Y5gxejP-vshAAWWDF_gAdU7AA</recordid><startdate>20171026</startdate><enddate>20171026</enddate><creator>Diamandis, Eleftherios P.</creator><creator>Stanczyk, Frank Z.</creator><creator>Wheeler, Sarah</creator><creator>Mathew, Anu</creator><creator>Stengelin, Martin</creator><creator>Nikolenko, Galina</creator><creator>Glezer, Eli N.</creator><creator>Brown, Marshall D.</creator><creator>Zheng, Yingye</creator><creator>Chen, Yen-Hao</creator><creator>Wu, Hsiao-Li</creator><creator>Azziz, Ricardo</creator><general>De Gruyter</general><general>Walter De Gruyter & Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171026</creationdate><title>Serum complexed and free prostate-specific antigen (PSA) for the diagnosis of the polycystic ovarian syndrome (PCOS)</title><author>Diamandis, Eleftherios P. ; Stanczyk, Frank Z. ; Wheeler, Sarah ; Mathew, Anu ; Stengelin, Martin ; Nikolenko, Galina ; Glezer, Eli N. ; Brown, Marshall D. ; Zheng, Yingye ; Chen, Yen-Hao ; Wu, Hsiao-Li ; Azziz, Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-517da977a84c48e4a05c8be8883e1f07418756650740aa4ce601c83069d448423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>androgen-regulated genes</topic><topic>Antigens</topic><topic>Area Under Curve</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Confidence intervals</topic><topic>Cross-Sectional Studies</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Hip</topic><topic>hirsutism</topic><topic>Hormones</topic><topic>Humans</topic><topic>hyperandrogenism</topic><topic>Immunoassay</topic><topic>Luminescent Measurements</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Ovulation</topic><topic>polycystic ovarian syndrome</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - diagnosis</topic><topic>Prostate</topic><topic>Prostate-specific antigen</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Reagent Kits, Diagnostic</topic><topic>ROC Curve</topic><topic>serum biomarkers</topic><topic>Steroid hormones</topic><topic>Steroids</topic><topic>Testosterone</topic><topic>urine biomarkers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diamandis, Eleftherios P.</creatorcontrib><creatorcontrib>Stanczyk, Frank Z.</creatorcontrib><creatorcontrib>Wheeler, Sarah</creatorcontrib><creatorcontrib>Mathew, Anu</creatorcontrib><creatorcontrib>Stengelin, Martin</creatorcontrib><creatorcontrib>Nikolenko, Galina</creatorcontrib><creatorcontrib>Glezer, Eli N.</creatorcontrib><creatorcontrib>Brown, Marshall D.</creatorcontrib><creatorcontrib>Zheng, Yingye</creatorcontrib><creatorcontrib>Chen, Yen-Hao</creatorcontrib><creatorcontrib>Wu, Hsiao-Li</creatorcontrib><creatorcontrib>Azziz, Ricardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diamandis, Eleftherios P.</au><au>Stanczyk, Frank Z.</au><au>Wheeler, Sarah</au><au>Mathew, Anu</au><au>Stengelin, Martin</au><au>Nikolenko, Galina</au><au>Glezer, Eli N.</au><au>Brown, Marshall D.</au><au>Zheng, Yingye</au><au>Chen, Yen-Hao</au><au>Wu, Hsiao-Li</au><au>Azziz, Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum complexed and free prostate-specific antigen (PSA) for the diagnosis of the polycystic ovarian syndrome (PCOS)</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clin Chem Lab Med</addtitle><date>2017-10-26</date><risdate>2017</risdate><volume>55</volume><issue>11</issue><spage>1789</spage><epage>1797</epage><pages>1789-1797</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>Polycystic ovarian syndrome (PCOS) is a common cause of reproductive and metabolic dysfunction. We hypothesized that serum prostate-specific antigen (PSA) may constitute a new biomarker for hyperandrogenism in PCOS.
We conducted a cross-sectional study of 45 women with PCOS and 40 controls. Serum from these women was analyzed for androgenic steroids and for complexed PSA (cPSA) and free PSA (fPSA) with a novel fifth- generation assay with a sensitivity of ~10 fg/mL for cPSA and 140 fg/mL for fPSA.
cPSA and fPSA levels were about three times higher in PCOS compared to controls. However, in PCOS, cPSA and fPSA did not differ according to waist-to-hip ratio, Ferriman-Gallwey score, or degree of hyperandrogenemia or oligo-ovulation. In PCOS and control women, serum cPSA and fPSA levels were highly correlated with each other, and with free and total testosterone levels, but not with other hormones. Adjusting for age, body mass index (BMI) and race, cPSA was significantly associated with PCOS, with an odds ratio (OR) of 5.67 (95% confidence interval [CI]: 1.86, 22.0). The OR of PCOS for fPSA was 7.04 (95% CI: 1.65, 40.4). A multivariate model that included age, BMI, race and cPSA yielded an area-under-the-receiver-operating-characteristic curve of 0.89.
Serum cPSA and fPSA are novel biomarkers for hyperandrogenism in PCOS and may have value for disease diagnosis.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>28361781</pmid><doi>10.1515/cclm-2016-1124</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical chemistry and laboratory medicine, 2017-10, Vol.55 (11), p.1789-1797 |
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| language | eng |
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| source | MEDLINE; De Gruyter journals |
| subjects | Adult androgen-regulated genes Antigens Area Under Curve Biomarkers Biomarkers - blood Body mass Body Mass Index Confidence intervals Cross-Sectional Studies Diagnosis Female Hip hirsutism Hormones Humans hyperandrogenism Immunoassay Luminescent Measurements Multivariate Analysis Odds Ratio Ovulation polycystic ovarian syndrome Polycystic ovary syndrome Polycystic Ovary Syndrome - diagnosis Prostate Prostate-specific antigen Prostate-Specific Antigen - blood Reagent Kits, Diagnostic ROC Curve serum biomarkers Steroid hormones Steroids Testosterone urine biomarkers |
| title | Serum complexed and free prostate-specific antigen (PSA) for the diagnosis of the polycystic ovarian syndrome (PCOS) |
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