DNAJB1–PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

A segmental deletion resulting in DNAJB1–PRKACA gene fusion is now recognized as the signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents and young adults. Here we implement CRISPR-Cas9 genome editing and transp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-12, Vol.114 (50), p.13076-13084
Hauptverfasser:	Kastenhuber, Edward R., Lalazar, Gadi, Houlihan, Shauna L., Tschaharganeh, Darjus F., Baslan, Timour, Chen, Chi-Chao, Requena, David, Tian, Sha, Bosbach, Benedikt, Wilkinson, John E., Simon, Sanford M., Lowe, Scott W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescents Adult Adults Animals Base Sequence beta Catenin - genetics Biological Sciences Carcinogenesis - chemically induced Carcinogenesis - genetics Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Chromosomes, Human, Pair 19 - genetics Clustered Regularly Interspaced Short Palindromic Repeats - genetics Cohort Studies CRISPR Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - genetics Female Fibrosis Fusion protein Gene deletion Gene expression Gene Expression Regulation, Neoplastic Gene fusion Gene transfer Genomes Hepatocellular carcinoma Hepatotoxicity HSP40 Heat-Shock Proteins - genetics Humans INAUGURAL ARTICLE Liver Liver - drug effects Liver - pathology Liver - physiology Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - genetics Liver Regeneration - genetics Medical treatment Mice Mice, Inbred C57BL Mutation Oncogene Proteins, Fusion - genetics Proteins Pyridines - toxicity Sequence Deletion - genetics Teenagers Tumorigenesis Tumors Wnt protein Young Adult Young adults β-Catenin
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