In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp
combinations of isavuconazole with echinocandins were evaluated against 30 strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based me...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2018-01, Vol.62 (1) |
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| container_title | Antimicrobial agents and chemotherapy |
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| creator | Raffetin, A Courbin, V Jullien, V Dannaoui, E |
| description | combinations of isavuconazole with echinocandins were evaluated against 30
strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based method, indifferent interactions were found for all strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergism in 4/30 strains, and antagonism in 2/30 strains. |
| doi_str_mv | 10.1128/AAC.01382-17 |
| format | Article |
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strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based method, indifferent interactions were found for all strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergism in 4/30 strains, and antagonism in 2/30 strains.</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01382-17</identifier><identifier>PMID: 29038263</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Anidulafungin ; Antifungal Agents ; Aspergillus flavus ; Aspergillus fumigatus ; Aspergillus nidulans ; Aspergillus niger ; Life Sciences ; Micafungin ; Nitriles ; Pyridines ; Susceptibility ; Triazoles</subject><ispartof>Antimicrobial agents and chemotherapy, 2018-01, Vol.62 (1)</ispartof><rights>Copyright © 2017 American Society for Microbiology.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2017 American Society for Microbiology. 2017 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a452t-d1c5b7b4c6579c85736a0d1d2e9bbbd1af61052be628ceafc7901f62c94785a73</citedby><cites>FETCH-LOGICAL-a452t-d1c5b7b4c6579c85736a0d1d2e9bbbd1af61052be628ceafc7901f62c94785a73</cites><orcidid>0000-0002-2817-3830</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740304/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740304/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29038263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.u-pec.fr/hal-03997741$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Raffetin, A</creatorcontrib><creatorcontrib>Courbin, V</creatorcontrib><creatorcontrib>Jullien, V</creatorcontrib><creatorcontrib>Dannaoui, E</creatorcontrib><title>In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>combinations of isavuconazole with echinocandins were evaluated against 30
strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based method, indifferent interactions were found for all strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergism in 4/30 strains, and antagonism in 2/30 strains.</description><subject>Anidulafungin</subject><subject>Antifungal Agents</subject><subject>Aspergillus flavus</subject><subject>Aspergillus fumigatus</subject><subject>Aspergillus nidulans</subject><subject>Aspergillus niger</subject><subject>Life Sciences</subject><subject>Micafungin</subject><subject>Nitriles</subject><subject>Pyridines</subject><subject>Susceptibility</subject><subject>Triazoles</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kUFrFDEYhkNR7Fq99VxyFZyaZCbJ5FIYlmoXFgRtvYYvmcxuymwyTmZW9NebdbXVgqePJM_7wJcXoXNKLill9bumWV4SWtasoPIELShRdSG4Es_QghAhiqom1Sl6mdI9yWeuyAt0yhTJAVEu0NdVwF_8NEa8jDvjA0w-Bhw7vEqwn20M8CP2Dn_z0xZf260P0UJofUgYNpDHhJsDUHyek3XD5E2GM4CLTy75NEHIQBrcuPF9PyechuEVet5Bn9zr3_MM3b2_vl3eFOuPH1bLZl1AxdlUtNRyI01lBZfK1lyWAkhLW-aUMaal0AlKODNOsNo66KxUhHaCWVXJmoMsz9DV0TvMZuda68I0Qq-H0e9g_K4jeP3vS_BbvYl7zWVFSlJlwZujYPskdtOs9eGOlEpJWdE9zezbI2vHmNLouocAJfpQk8416V81aSof1ZB2TN_HeQz5K_7HXvy9x4P4T4flT9YZnII</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Raffetin, A</creator><creator>Courbin, V</creator><creator>Jullien, V</creator><creator>Dannaoui, E</creator><general>American Society for Microbiology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2817-3830</orcidid></search><sort><creationdate>20180101</creationdate><title>In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp</title><author>Raffetin, A ; Courbin, V ; Jullien, V ; Dannaoui, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a452t-d1c5b7b4c6579c85736a0d1d2e9bbbd1af61052be628ceafc7901f62c94785a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anidulafungin</topic><topic>Antifungal Agents</topic><topic>Aspergillus flavus</topic><topic>Aspergillus fumigatus</topic><topic>Aspergillus nidulans</topic><topic>Aspergillus niger</topic><topic>Life Sciences</topic><topic>Micafungin</topic><topic>Nitriles</topic><topic>Pyridines</topic><topic>Susceptibility</topic><topic>Triazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raffetin, A</creatorcontrib><creatorcontrib>Courbin, V</creatorcontrib><creatorcontrib>Jullien, V</creatorcontrib><creatorcontrib>Dannaoui, E</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raffetin, A</au><au>Courbin, V</au><au>Jullien, V</au><au>Dannaoui, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>62</volume><issue>1</issue><issn>0066-4804</issn><eissn>1098-6596</eissn><abstract>combinations of isavuconazole with echinocandins were evaluated against 30
strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based method, indifferent interactions were found for all strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergism in 4/30 strains, and antagonism in 2/30 strains.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>29038263</pmid><doi>10.1128/AAC.01382-17</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2817-3830</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Free E-Journal (出版社公開部分のみ）; PubMed Central |
| subjects | Anidulafungin Antifungal Agents Aspergillus flavus Aspergillus fumigatus Aspergillus nidulans Aspergillus niger Life Sciences Micafungin Nitriles Pyridines Susceptibility Triazoles |
| title | In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp |
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