HID-1 controls formation of large dense core vesicles by influencing cargo sorting and trans -Golgi network acidification

Large dense core vesicles (LDCVs) mediate the regulated release of neuropeptides and peptide hormones. They form at the -Golgi network (TGN), where their soluble content aggregates to form a dense core, but the mechanisms controlling biogenesis are still not completely understood. Recent studies hav...

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Veröffentlicht in:	Molecular biology of the cell 2017-12, Vol.28 (26), p.3870-3880
Hauptverfasser:	Hummer, Blake H, de Leeuw, Noah F, Burns, Christian, Chen, Lan, Joens, Matthew S, Hosford, Bethany, Fitzpatrick, James A J, Asensio, Cedric S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Exocytosis Gene Knockout Techniques Golgi Apparatus - metabolism HEK293 Cells Homeodomain Proteins - metabolism Humans Membrane Proteins - metabolism Neuropeptides - metabolism PC12 Cells Protein Transport Rats Secretory Vesicles - metabolism trans-Golgi Network - metabolism Vacuolar Proton-Translocating ATPases - metabolism
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