Functional pharmacological characterization of SER100 in cardiovascular health and disease

Background and Purpose SER100 is a selective nociceptin (NOP) receptor agonist with sodium‐potassium‐sparing aquaretic and anti‐natriuretic activity. This study was designed to characterize the functional cardiovascular pharmacology of SER100 in vitro and in vivo, including experimental models of ca...

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Veröffentlicht in:	British journal of pharmacology 2016-12, Vol.173 (23), p.3386-3401
Hauptverfasser:	Villar, Inmaculada C, Bubb, Kristen J, Moyes, Amie J, Steiness, Eva, Gulbrandsen, Trygve, Levy, Finn Olav, Hobbs, Adrian J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Aorta Aorta - drug effects Aorta - metabolism Arteries Blood pressure Blood Pressure - drug effects Cardiovascular disease Cardiovascular Diseases - drug therapy Cardiovascular Diseases - physiopathology Cardiovascular System - drug effects Cardiovascular System - metabolism Circulatory system Disease Models, Animal Echocardiography EKG Heart diseases Heart rate Heart Rate - drug effects Hemodynamics Hypertension - drug therapy Hypertension - physiopathology Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - physiopathology Hypoxia Male Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Mice Mice, Inbred C57BL Mice, Knockout Nociceptin Oligopeptides - pharmacology Pulmonary hypertension Rats Rats, Inbred SHR Rats, Inbred WKY Rats, Sprague-Dawley Receptors, Opioid - agonists Research Paper Research Papers Rodents Sodium Vagus nerve
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