Upregulation of SPS100 gene expression by an antisense RNA via a switch of mRNA isoforms with different stabilities

Pervasive transcription of genomes generates multiple classes of non-coding RNAs. One of these classes are stable long non-coding RNAs which overlap coding genes in antisense direction (asRNAs). The function of such asRNAs is not fully understood but several cases of antisense-dependent gene express...

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Veröffentlicht in:	Nucleic acids research 2017-11, Vol.45 (19), p.11144-11158
Hauptverfasser:	Bunina, Daria, Štefl, Martin, Huber, Florian, Khmelinskii, Anton, Meurer, Matthias, Barry, Joseph D, Kats, Ilia, Kirrmaier, Daniel, Huber, Wolfgang, Knop, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Expression Regulation, Fungal Gene regulation, Chromatin and Epigenetics Immunoblotting Microscopy, Fluorescence Reverse Transcriptase Polymerase Chain Reaction RNA Isoforms - genetics RNA Stability - genetics RNA, Antisense - genetics Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Spores, Fungal - genetics Spores, Fungal - metabolism Time-Lapse Imaging - methods Up-Regulation
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