CRISPR-mediated isolation of specific megabase segments of genomic DNA

Megabase-sized, complex, repetitive regions of genomes are poorly studied, due to the technical and computational challenges inherent to both assembling precise reference sequences and accurately assessing structural variation across contiguous megabase DNA regions. Here we describe a strategy to ov...

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Veröffentlicht in:	Nucleic acids research 2017-11, Vol.45 (19), p.e165-e165
Hauptverfasser:	Bennett-Baker, Pamela E, Mueller, Jacob L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CRISPR-Cas Systems DNA - genetics DNA - isolation & purification DNA, Fungal - genetics Electrophoresis, Gel, Pulsed-Field - methods Genome - genetics High-Throughput Nucleotide Sequencing - methods Methods Online Mice Reproducibility of Results Saccharomyces cerevisiae - genetics
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