Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients

RNAs within extracellular vesicles (EVs) have potential as diagnostic biomarkers for patients with cancer and are identified in a variety of biofluids. Glioblastomas (GBMs) release EVs containing RNA into cerebrospinal fluid (CSF). Here we describe a multi-institutional study of RNA extracted from C...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2017-10, Vol.19 (11), p.1494-1502
Hauptverfasser:	Figueroa, Javier M, Skog, Johan, Akers, Johnny, Li, Hongying, Komotar, Ricardo, Jensen, Randy, Ringel, Florian, Yang, Isaac, Kalkanis, Steven, Thompson, Reid, LoGuidice, Lori, Berghoff, Emily, Parsa, Andrew, Liau, Linda, Curry, William, Cahill, Daniel, Bettegowda, Chetan, Lang, Frederick F, Chiocca, E Antonio, Henson, John, Kim, Ryan, Breakefield, Xandra, Chen, Clark, Messer, Karen, Hochberg, Fred, Carter, Bob S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Basic and Translational Investigations Biomarkers, Tumor - genetics Brain Neoplasms - cerebrospinal fluid Brain Neoplasms - genetics Brain Neoplasms - pathology ErbB Receptors - genetics Extracellular Vesicles - metabolism Extracellular Vesicles - pathology Female Follow-Up Studies Gene Amplification Gene Expression Regulation, Neoplastic Glioblastoma - cerebrospinal fluid Glioblastoma - genetics Glioblastoma - pathology Humans Male Middle Aged Mutation Prognosis Signal Transduction Young Adult
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