Incremental effects of antihypertensive drugs: instrumental variable analysis

To assess the incremental effects of adding extra antihypertensive drugs from a new class to a patient's regimen. Instrumental variable analysis of data from SPRINT (Systolic Blood Pressure Intervention Trial). To account for confounding by indication-when treatments seem less effective if they...

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Veröffentlicht in:	BMJ (Online) 2017-12, Vol.359, p.j5542-j5542
Hauptverfasser:	Markovitz, Adam A, Mack, Jacob A, Nallamothu, Brahmajee K, Ayanian, John Z, Ryan, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensive Agents - classification Antihypertensive Agents - pharmacology Blood Pressure - drug effects Cardiovascular Diseases - drug therapy Female Humans Hypertension - complications Hypertension - drug therapy Hypertension - epidemiology Hypertension - physiopathology Male Middle Aged Outcome Assessment (Health Care) Randomized Controlled Trials as Topic Risk Factors Systole - drug effects Treatment Outcome
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Beschreibung
Zusammenfassung:	To assess the incremental effects of adding extra antihypertensive drugs from a new class to a patient's regimen. Instrumental variable analysis of data from SPRINT (Systolic Blood Pressure Intervention Trial). To account for confounding by indication-when treatments seem less effective if they are administered to sicker patients-randomization status was used as the instrumental variable. Patients' randomization status was either intensive (systolic blood pressure target
ISSN:	0959-8138 1756-1833
DOI:	10.1136/bmj.j5542