Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NO/cGMP/ATP-Sensitive-K+ Channel Activation Dependent
Boswellia dalzielii (B. dalzielii) is traditionally used in the treatment of rheumatism, pain, and inflammation. The present investigation evaluates the property and possible mechanism of action of the methanolic extract of B. dalzielii (BDME) on inflammatory and neuropathic pain models. Effects of...
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| creator | Yousseu Nana, William Dawe, Amadou Ngouonpe Wembe, Alain Mbiantcha, M. Ateufack, G. |
| description | Boswellia dalzielii (B. dalzielii) is traditionally used in the treatment of rheumatism, pain, and inflammation. The present investigation evaluates the property and possible mechanism of action of the methanolic extract of B. dalzielii (BDME) on inflammatory and neuropathic pain models. Effects of BDME (250 and 500 mg/kg), orally administered, were verified in mechanical hypernociception induced by LPS or PGE2. Mechanical hyperalgesia, cold allodynia, and heat hyperalgesia were used in vincristine-induced neuropathic pain. NW-nitro-L-arginine methyl ester (inhibitor of nitric oxide synthase), glibenclamide (ATP-sensitive potassium channel blocker), methylene blue (cGMP blocker), or naloxone (opioid antagonist receptor) has been used to evaluate the therapeutic effects of BDME on PGE2-induced hyperalgesia. Chemical profile of BDME was determined by using HPLC-XESI-PDA/MS. BDME showed significant antinociceptive effects in inflammatory pain caused by LPS and PGE2. The extract also significantly inhibited neuropathic pain induced by vincristine. The antinociceptive property of BDME in PGE2 model was significantly blocked by L-NAME, glibenclamide, methylene blue, or naloxone. The present work reveals the antinociceptive activities of BDME both in inflammatory and in neuropathic models of pain. This plant extract may be acting firstly by binding to opioid receptors and secondly by activating the NO/cGMP/ATP-sensitive-K+ channel pathway. |
| doi_str_mv | 10.1155/2017/6374907 |
| format | Article |
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(Burseraceae) in Rats Are NO/cGMP/ATP-Sensitive-K+ Channel Activation Dependent</title><source>PubMed Central Open Access</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Yousseu Nana, William ; Dawe, Amadou ; Ngouonpe Wembe, Alain ; Mbiantcha, M. ; Ateufack, G.</creator><contributor>Capasso, Raffaele</contributor><creatorcontrib>Yousseu Nana, William ; Dawe, Amadou ; Ngouonpe Wembe, Alain ; Mbiantcha, M. ; Ateufack, G. ; Capasso, Raffaele</creatorcontrib><description>Boswellia dalzielii (B. dalzielii) is traditionally used in the treatment of rheumatism, pain, and inflammation. The present investigation evaluates the property and possible mechanism of action of the methanolic extract of B. dalzielii (BDME) on inflammatory and neuropathic pain models. Effects of BDME (250 and 500 mg/kg), orally administered, were verified in mechanical hypernociception induced by LPS or PGE2. Mechanical hyperalgesia, cold allodynia, and heat hyperalgesia were used in vincristine-induced neuropathic pain. NW-nitro-L-arginine methyl ester (inhibitor of nitric oxide synthase), glibenclamide (ATP-sensitive potassium channel blocker), methylene blue (cGMP blocker), or naloxone (opioid antagonist receptor) has been used to evaluate the therapeutic effects of BDME on PGE2-induced hyperalgesia. Chemical profile of BDME was determined by using HPLC-XESI-PDA/MS. BDME showed significant antinociceptive effects in inflammatory pain caused by LPS and PGE2. The extract also significantly inhibited neuropathic pain induced by vincristine. The antinociceptive property of BDME in PGE2 model was significantly blocked by L-NAME, glibenclamide, methylene blue, or naloxone. The present work reveals the antinociceptive activities of BDME both in inflammatory and in neuropathic models of pain. This plant extract may be acting firstly by binding to opioid receptors and secondly by activating the NO/cGMP/ATP-sensitive-K+ channel pathway.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2017/6374907</identifier><identifier>PMID: 29362589</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Arginine ; ATP ; Bark ; Boswellia ; Burseraceae ; Cyclic GMP ; Glibenclamide ; Herbal medicine ; High-performance liquid chromatography ; Hyperalgesia ; Inflammation ; Lipopolysaccharides ; Liquid chromatography ; Methylene blue ; Naloxone ; Neuralgia ; NG-Nitroarginine methyl ester ; Nitric oxide ; Nitric-oxide synthase ; Nitroarginine ; Opioid receptors ; Oral administration ; Pain perception ; Plant extracts ; Potassium ; Potassium channels ; Prostaglandin E2 ; Rats ; Rodents ; Trees ; Vincristine</subject><ispartof>Evidence-based complementary and alternative medicine, 2017-01, Vol.2017 (2017), p.1-12</ispartof><rights>Copyright © 2017 Marius Mbiantcha et al.</rights><rights>Copyright © 2017 Marius Mbiantcha et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Marius Mbiantcha et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-79a9cf4c2848b2e89b6f9f21c9dd0ac399ab7ffb9d5027472698865d36fbe20a3</citedby><cites>FETCH-LOGICAL-c433t-79a9cf4c2848b2e89b6f9f21c9dd0ac399ab7ffb9d5027472698865d36fbe20a3</cites><orcidid>0000-0001-6113-7615 ; 0000-0001-8586-6150</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736925/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736925/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29362589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Capasso, Raffaele</contributor><creatorcontrib>Yousseu Nana, William</creatorcontrib><creatorcontrib>Dawe, Amadou</creatorcontrib><creatorcontrib>Ngouonpe Wembe, Alain</creatorcontrib><creatorcontrib>Mbiantcha, M.</creatorcontrib><creatorcontrib>Ateufack, G.</creatorcontrib><title>Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NO/cGMP/ATP-Sensitive-K+ Channel Activation Dependent</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Boswellia dalzielii (B. dalzielii) is traditionally used in the treatment of rheumatism, pain, and inflammation. The present investigation evaluates the property and possible mechanism of action of the methanolic extract of B. dalzielii (BDME) on inflammatory and neuropathic pain models. Effects of BDME (250 and 500 mg/kg), orally administered, were verified in mechanical hypernociception induced by LPS or PGE2. Mechanical hyperalgesia, cold allodynia, and heat hyperalgesia were used in vincristine-induced neuropathic pain. NW-nitro-L-arginine methyl ester (inhibitor of nitric oxide synthase), glibenclamide (ATP-sensitive potassium channel blocker), methylene blue (cGMP blocker), or naloxone (opioid antagonist receptor) has been used to evaluate the therapeutic effects of BDME on PGE2-induced hyperalgesia. Chemical profile of BDME was determined by using HPLC-XESI-PDA/MS. BDME showed significant antinociceptive effects in inflammatory pain caused by LPS and PGE2. The extract also significantly inhibited neuropathic pain induced by vincristine. The antinociceptive property of BDME in PGE2 model was significantly blocked by L-NAME, glibenclamide, methylene blue, or naloxone. The present work reveals the antinociceptive activities of BDME both in inflammatory and in neuropathic models of pain. This plant extract may be acting firstly by binding to opioid receptors and secondly by activating the NO/cGMP/ATP-sensitive-K+ channel pathway.</description><subject>Arginine</subject><subject>ATP</subject><subject>Bark</subject><subject>Boswellia</subject><subject>Burseraceae</subject><subject>Cyclic GMP</subject><subject>Glibenclamide</subject><subject>Herbal medicine</subject><subject>High-performance liquid chromatography</subject><subject>Hyperalgesia</subject><subject>Inflammation</subject><subject>Lipopolysaccharides</subject><subject>Liquid chromatography</subject><subject>Methylene blue</subject><subject>Naloxone</subject><subject>Neuralgia</subject><subject>NG-Nitroarginine methyl ester</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Nitroarginine</subject><subject>Opioid receptors</subject><subject>Oral administration</subject><subject>Pain perception</subject><subject>Plant extracts</subject><subject>Potassium</subject><subject>Potassium channels</subject><subject>Prostaglandin E2</subject><subject>Rats</subject><subject>Rodents</subject><subject>Trees</subject><subject>Vincristine</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkstu1DAUhiMEoqWwY40ssSkq6Ti-xPEGKTOUFtHSihaJXeQ4J4xLxh5spwVeixfEo5kOlxWrY_l8_s_Ff5Y9LfBhUXA-IbgQk5IKJrG4l-0WghU5I1V1f3sWn3ayRyFcY0ykEOJhtkMkLQmv5G72s7bRWKeNhmU0N4BqnYKJBgJyPYpzQGcQ58q6wWh09C16peNd5jLCAk2V_7K6mLpwC8NgFOrU8MPAYAw6GaOeH6L96egDpJeg4AUyFn1QMaDaA3p_PtHHZxeT-uoivwQbzKqH_N0BmqWSFoZ1OyoaZ9FrWILtwMbH2YNeDQGebOJe9vHN0dXsJD89P347q09zzSiNuZBK6p5pUrGqJVDJtuxlTwotuw4rTaVUrej7VnYcE8EEKWVVlbyjZd8CwYruZa_WusuxXUCnU2mvhmbpzUL5741Tpvk7Y828-exuGi5oKQlPAvsbAe--jhBiszBBpyUpC24MTSElrjgvJU7o83_Qazd6m8ZLVEUZKzkpE_VyTWnvQvDQb5spcLNyQ7NyQ7NxQ8Kf_TnAFr77_gQcrIG5sZ26Nf8pB4mBXv2mC55cxugvC2bIVw</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Yousseu Nana, William</creator><creator>Dawe, Amadou</creator><creator>Ngouonpe Wembe, Alain</creator><creator>Mbiantcha, M.</creator><creator>Ateufack, G.</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6113-7615</orcidid><orcidid>https://orcid.org/0000-0001-8586-6150</orcidid></search><sort><creationdate>20170101</creationdate><title>Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NO/cGMP/ATP-Sensitive-K+ Channel Activation Dependent</title><author>Yousseu Nana, William ; Dawe, Amadou ; Ngouonpe Wembe, Alain ; Mbiantcha, M. ; Ateufack, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-79a9cf4c2848b2e89b6f9f21c9dd0ac399ab7ffb9d5027472698865d36fbe20a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Arginine</topic><topic>ATP</topic><topic>Bark</topic><topic>Boswellia</topic><topic>Burseraceae</topic><topic>Cyclic GMP</topic><topic>Glibenclamide</topic><topic>Herbal medicine</topic><topic>High-performance liquid chromatography</topic><topic>Hyperalgesia</topic><topic>Inflammation</topic><topic>Lipopolysaccharides</topic><topic>Liquid chromatography</topic><topic>Methylene blue</topic><topic>Naloxone</topic><topic>Neuralgia</topic><topic>NG-Nitroarginine methyl ester</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Nitroarginine</topic><topic>Opioid receptors</topic><topic>Oral administration</topic><topic>Pain perception</topic><topic>Plant extracts</topic><topic>Potassium</topic><topic>Potassium channels</topic><topic>Prostaglandin E2</topic><topic>Rats</topic><topic>Rodents</topic><topic>Trees</topic><topic>Vincristine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yousseu Nana, William</creatorcontrib><creatorcontrib>Dawe, Amadou</creatorcontrib><creatorcontrib>Ngouonpe Wembe, Alain</creatorcontrib><creatorcontrib>Mbiantcha, M.</creatorcontrib><creatorcontrib>Ateufack, G.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yousseu Nana, William</au><au>Dawe, Amadou</au><au>Ngouonpe Wembe, Alain</au><au>Mbiantcha, M.</au><au>Ateufack, G.</au><au>Capasso, Raffaele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NO/cGMP/ATP-Sensitive-K+ Channel Activation Dependent</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Boswellia dalzielii (B. dalzielii) is traditionally used in the treatment of rheumatism, pain, and inflammation. The present investigation evaluates the property and possible mechanism of action of the methanolic extract of B. dalzielii (BDME) on inflammatory and neuropathic pain models. Effects of BDME (250 and 500 mg/kg), orally administered, were verified in mechanical hypernociception induced by LPS or PGE2. Mechanical hyperalgesia, cold allodynia, and heat hyperalgesia were used in vincristine-induced neuropathic pain. NW-nitro-L-arginine methyl ester (inhibitor of nitric oxide synthase), glibenclamide (ATP-sensitive potassium channel blocker), methylene blue (cGMP blocker), or naloxone (opioid antagonist receptor) has been used to evaluate the therapeutic effects of BDME on PGE2-induced hyperalgesia. Chemical profile of BDME was determined by using HPLC-XESI-PDA/MS. BDME showed significant antinociceptive effects in inflammatory pain caused by LPS and PGE2. The extract also significantly inhibited neuropathic pain induced by vincristine. The antinociceptive property of BDME in PGE2 model was significantly blocked by L-NAME, glibenclamide, methylene blue, or naloxone. The present work reveals the antinociceptive activities of BDME both in inflammatory and in neuropathic models of pain. This plant extract may be acting firstly by binding to opioid receptors and secondly by activating the NO/cGMP/ATP-sensitive-K+ channel pathway.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29362589</pmid><doi>10.1155/2017/6374907</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6113-7615</orcidid><orcidid>https://orcid.org/0000-0001-8586-6150</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Arginine ATP Bark Boswellia Burseraceae Cyclic GMP Glibenclamide Herbal medicine High-performance liquid chromatography Hyperalgesia Inflammation Lipopolysaccharides Liquid chromatography Methylene blue Naloxone Neuralgia NG-Nitroarginine methyl ester Nitric oxide Nitric-oxide synthase Nitroarginine Opioid receptors Oral administration Pain perception Plant extracts Potassium Potassium channels Prostaglandin E2 Rats Rodents Trees Vincristine |
| title | Antinociceptive Activities of the Methanolic Extract of the Stem Bark of Boswellia dalzielii Hutch. (Burseraceae) in Rats Are NO/cGMP/ATP-Sensitive-K+ Channel Activation Dependent |
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