Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection
Epstein–Barr virus (EBV) is a common human pathogen that infects over 95% of the population worldwide. In the present study, the whole transcriptome microarray data were generated from peripheral blood mononuclear cells from Chinese children with acute infectious mononucleosis (AIM) and chronic acti...
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| Veröffentlicht in: | Scientific reports 2017-12, Vol.7 (1), p.17775-16, Article 17775 |
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| creator | Zhong, Huaqing Hu, Xinran Janowski, Andrew B. Storch, Gregory A. Su, Liyun Cao, Lingfeng Yu, Jinsheng Xu, Jin |
| description | Epstein–Barr virus (EBV) is a common human pathogen that infects over 95% of the population worldwide. In the present study, the whole transcriptome microarray data were generated from peripheral blood mononuclear cells from Chinese children with acute infectious mononucleosis (AIM) and chronic active EBV infection (CAEBV) that were also compared with a publicly available microarray dataset from a study of American college students with AIM. Our study characterized for the first time a broad spectrum of molecular signatures in AIM and CAEBV. The key findings from the transcriptome profiling were validated with qPCR and flow cytometry assays. The most important finding in our study is the discovery of predominant γδ TCR expression and γδ T cell expansion in AIM. This finding, in combination with the striking up-regulation of
CD3
,
CD8 and CD94
, suggests that CD8+ T cells and CD94+ NK cells may play a major role in AIM. Moreover, the unique up-regulation of
CD64A
/
B
and its significant correlation with the monocyte marker
CD14
was observed in CAEBV and that implies an important role of monocytes in CAEBV. In conclusion, our study reveals major cell types (particularly γδ T cells) in the host cellular immune response against AIM and CAEBV. |
| doi_str_mv | 10.1038/s41598-017-18195-z |
| format | Article |
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CD3
,
CD8 and CD94
, suggests that CD8+ T cells and CD94+ NK cells may play a major role in AIM. Moreover, the unique up-regulation of
CD64A
/
B
and its significant correlation with the monocyte marker
CD14
was observed in CAEBV and that implies an important role of monocytes in CAEBV. In conclusion, our study reveals major cell types (particularly γδ T cells) in the host cellular immune response against AIM and CAEBV.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-18195-z</identifier><identifier>PMID: 29259291</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/31 ; 38/39 ; 38/61 ; 38/77 ; 38/90 ; 631/250/255/2514 ; 631/326/421 ; Antigens, CD - immunology ; Case-Control Studies ; CD14 antigen ; CD3 antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Child ; Child, Preschool ; Children ; Chronic Disease ; Chronic infection ; College students ; Colleges & universities ; Datasets ; DNA microarrays ; Epstein-Barr virus ; Epstein-Barr Virus Infections - immunology ; Female ; Flow cytometry ; Flow Cytometry - methods ; Gene expression ; Gene Expression Profiling - methods ; Herpesvirus 4, Human - immunology ; Humanities and Social Sciences ; Humans ; Immune response ; Immune response (cell-mediated) ; Immunity, Cellular - immunology ; Infections ; Infectious mononucleosis ; Infectious Mononucleosis - immunology ; Killer Cells, Natural - immunology ; Laboratories ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - immunology ; Lymphocytes ; Lymphocytes T ; Male ; Monocytes ; Mononucleosis ; multidisciplinary ; Peripheral blood mononuclear cells ; Science ; Science (multidisciplinary) ; T cell receptors ; Transcriptome - immunology</subject><ispartof>Scientific reports, 2017-12, Vol.7 (1), p.17775-16, Article 17775</ispartof><rights>The Author(s) 2017</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-8aa36d44f1a4b1eb75ba30b7830d86af3292bf86985bcc061e273b9dc351372b3</citedby><cites>FETCH-LOGICAL-c474t-8aa36d44f1a4b1eb75ba30b7830d86af3292bf86985bcc061e273b9dc351372b3</cites><orcidid>0000-0003-3377-4304</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736708/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736708/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29259291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhong, Huaqing</creatorcontrib><creatorcontrib>Hu, Xinran</creatorcontrib><creatorcontrib>Janowski, Andrew B.</creatorcontrib><creatorcontrib>Storch, Gregory A.</creatorcontrib><creatorcontrib>Su, Liyun</creatorcontrib><creatorcontrib>Cao, Lingfeng</creatorcontrib><creatorcontrib>Yu, Jinsheng</creatorcontrib><creatorcontrib>Xu, Jin</creatorcontrib><title>Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Epstein–Barr virus (EBV) is a common human pathogen that infects over 95% of the population worldwide. In the present study, the whole transcriptome microarray data were generated from peripheral blood mononuclear cells from Chinese children with acute infectious mononucleosis (AIM) and chronic active EBV infection (CAEBV) that were also compared with a publicly available microarray dataset from a study of American college students with AIM. Our study characterized for the first time a broad spectrum of molecular signatures in AIM and CAEBV. The key findings from the transcriptome profiling were validated with qPCR and flow cytometry assays. The most important finding in our study is the discovery of predominant γδ TCR expression and γδ T cell expansion in AIM. This finding, in combination with the striking up-regulation of
CD3
,
CD8 and CD94
, suggests that CD8+ T cells and CD94+ NK cells may play a major role in AIM. Moreover, the unique up-regulation of
CD64A
/
B
and its significant correlation with the monocyte marker
CD14
was observed in CAEBV and that implies an important role of monocytes in CAEBV. In conclusion, our study reveals major cell types (particularly γδ T cells) in the host cellular immune response against AIM and CAEBV.</description><subject>13/1</subject><subject>13/31</subject><subject>38/39</subject><subject>38/61</subject><subject>38/77</subject><subject>38/90</subject><subject>631/250/255/2514</subject><subject>631/326/421</subject><subject>Antigens, CD - immunology</subject><subject>Case-Control Studies</subject><subject>CD14 antigen</subject><subject>CD3 antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Chronic Disease</subject><subject>Chronic infection</subject><subject>College students</subject><subject>Colleges & universities</subject><subject>Datasets</subject><subject>DNA microarrays</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - immunology</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Flow Cytometry - 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immunology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Laboratories</topic><topic>Leukocytes (mononuclear)</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Monocytes</topic><topic>Mononucleosis</topic><topic>multidisciplinary</topic><topic>Peripheral blood mononuclear cells</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>T cell receptors</topic><topic>Transcriptome - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhong, Huaqing</creatorcontrib><creatorcontrib>Hu, Xinran</creatorcontrib><creatorcontrib>Janowski, Andrew B.</creatorcontrib><creatorcontrib>Storch, Gregory A.</creatorcontrib><creatorcontrib>Su, Liyun</creatorcontrib><creatorcontrib>Cao, Lingfeng</creatorcontrib><creatorcontrib>Yu, Jinsheng</creatorcontrib><creatorcontrib>Xu, Jin</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, Huaqing</au><au>Hu, Xinran</au><au>Janowski, Andrew B.</au><au>Storch, Gregory A.</au><au>Su, Liyun</au><au>Cao, Lingfeng</au><au>Yu, Jinsheng</au><au>Xu, Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-12-19</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>17775</spage><epage>16</epage><pages>17775-16</pages><artnum>17775</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Epstein–Barr virus (EBV) is a common human pathogen that infects over 95% of the population worldwide. In the present study, the whole transcriptome microarray data were generated from peripheral blood mononuclear cells from Chinese children with acute infectious mononucleosis (AIM) and chronic active EBV infection (CAEBV) that were also compared with a publicly available microarray dataset from a study of American college students with AIM. Our study characterized for the first time a broad spectrum of molecular signatures in AIM and CAEBV. The key findings from the transcriptome profiling were validated with qPCR and flow cytometry assays. The most important finding in our study is the discovery of predominant γδ TCR expression and γδ T cell expansion in AIM. This finding, in combination with the striking up-regulation of
CD3
,
CD8 and CD94
, suggests that CD8+ T cells and CD94+ NK cells may play a major role in AIM. Moreover, the unique up-regulation of
CD64A
/
B
and its significant correlation with the monocyte marker
CD14
was observed in CAEBV and that implies an important role of monocytes in CAEBV. In conclusion, our study reveals major cell types (particularly γδ T cells) in the host cellular immune response against AIM and CAEBV.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29259291</pmid><doi>10.1038/s41598-017-18195-z</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-3377-4304</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 13/1 13/31 38/39 38/61 38/77 38/90 631/250/255/2514 631/326/421 Antigens, CD - immunology Case-Control Studies CD14 antigen CD3 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Child Child, Preschool Children Chronic Disease Chronic infection College students Colleges & universities Datasets DNA microarrays Epstein-Barr virus Epstein-Barr Virus Infections - immunology Female Flow cytometry Flow Cytometry - methods Gene expression Gene Expression Profiling - methods Herpesvirus 4, Human - immunology Humanities and Social Sciences Humans Immune response Immune response (cell-mediated) Immunity, Cellular - immunology Infections Infectious mononucleosis Infectious Mononucleosis - immunology Killer Cells, Natural - immunology Laboratories Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Lymphocytes Lymphocytes T Male Monocytes Mononucleosis multidisciplinary Peripheral blood mononuclear cells Science Science (multidisciplinary) T cell receptors Transcriptome - immunology |
| title | Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection |
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