IFNγ induces PD-L1 overexpression by JAK2/STAT1/IRF-1 signaling in EBV-positive gastric carcinoma

Programmed death-ligand 1 (PD-L1) acts as an immune checkpoint inhibitor in various cancers. PD-L1 is known to be more frequently expressed in EBV (+) gastric cancer (GC). However, the mechanisms underlying the regulation of PD-L1 expression in EBV (+) GC remain unclear. We investigated the basal an...

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Veröffentlicht in:	Scientific reports 2017-12, Vol.7 (1), p.17810-13, Article 17810
Hauptverfasser:	Moon, Ji Wook, Kong, Su-Kang, Kim, Byung Soo, Kim, Hyun Ji, Lim, Hyangsoon, Noh, Kyeonga, Kim, Younghye, Choi, Jung-Woo, Lee, Ju-Han, Kim, Young-Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/51 13/89 13/95 45 631/67/1504/1829 692/308/575 Apoptosis B7-H1 Antigen - genetics Cell Line, Tumor Chromatin Cytotoxicity Electrophoretic mobility Epstein-Barr virus Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - virology Gastric cancer Gene amplification Gene Expression Regulation, Neoplastic - genetics Herpesvirus 4, Human - pathogenicity Humanities and Social Sciences Humans Immune checkpoint inhibitors Immunoprecipitation Interferon regulatory factor 1 Interferon Regulatory Factor-1 - genetics Interferon-gamma - genetics Janus kinase 2 Janus Kinase 2 - genetics Ligands Lung cancer Lymphocytes multidisciplinary PD-L1 protein Proteins Proteins - genetics Science Science (multidisciplinary) Signal Transduction - genetics Stat1 protein STAT1 Transcription Factor - genetics Stomach Neoplasms - genetics Stomach Neoplasms - virology Transcription γ-Interferon
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