Micro- and Nanoscale Topographies on Silk Regulate Gene Expression of Human Corneal Epithelial Cells

Corneal basement membrane has topographical features that provide biophysical cues to direct cell adherence, migration, and proliferation. In this study, we hypothesize that varying topographic pitch created on silk films can alter epithelial cell morphology, adhesion, and the genetic expression inv...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2017-12, Vol.58 (14), p.6388-6398
Hauptverfasser:	Kang, Kai B, Lawrence, Brian D, Gao, X Raymond, Luo, Yuncin, Zhou, Qiang, Liu, Aihong, Guaiquil, Victor H, Rosenblatt, Mark I
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion - drug effects Cells, Cultured Cornea Cytoskeleton - drug effects Epithelial Cells - cytology Epithelial Cells - ultrastructure Epithelium, Corneal - cytology Gene Expression Profiling Gene Expression Regulation - drug effects Humans Silk - pharmacology Tissue Engineering - methods Tissue Scaffolds
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