Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats
Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control grou...
Gespeichert in:
| Veröffentlicht in: | Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-11 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 11 |
|---|---|
| container_issue | 2017 |
| container_start_page | 1 |
| container_title | Oxidative medicine and cellular longevity |
| container_volume | 2017 |
| creator | Song, Yisheng Xuan, Yaoxian Zheng, Gaoli Xin, Yanfei Li, Lili Liu, Fang Chen, Hao Zhang, Sheng Chen, Zhiqin Xie, Feng Sun, Junying You, Zhenqiang Chen, Guocan |
| description | Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5 ml/kg FPEs). Severe mammary gland hyperplasia was induced upon estradiol benzoate and progestin administration. FPEs could improve the pathological features of the animal model and reduce estrogen levels in the serum. Analysis of oxidant indices revealed that FPEs could increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, decrease malondialdehyde (MDA) level in the mammary glands and serum of the animal models, and decrease the proportion of cells positive for the oxidative DNA damage marker 8-oxo-dG in the mammary glands. Additionally, estradiol benzoate and progestin altered the levels of serum biochemical compounds such as aspartate transaminase (AST), total bilirubin (TBIL), and alanine transaminase (ALT), as well as hepatic oxidant indices such as SOD, GSH-Px, MDA, and 8-oxo-2′-deoxyguanosine (8-oxo-dG). These indices reverted to normal levels upon oral administration of a high dose of FPEs. Taken together, our results indicate that FPEs can protect the mammary glands and other visceral organs from oxidative damage. |
| doi_str_mv | 10.1155/2017/8235069 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5735651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A555850817</galeid><sourcerecordid>A555850817</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-18c82adbb4bdd4819d0ccb48b369c57bd9a2ad9fe3e784f365e2ebf985270b4f3</originalsourceid><addsrcrecordid>eNqNkd1rFDEUxQdRbK2--SwBXwRdm8wkM8mLUMpuW2ixiD6Hm4_ZTplJ1mRGXfCP9w67btUnIZCQ-8vJPfcUxUtG3zMmxGlJWXMqy0rQWj0qjpni5YIqxR8fzpQeFc9yvqe0rkrOnhZHpaqEooweFz9vopt6GGPakmXbejuS2JKVT4MPo3fkFjawBbL8MSawYyYxkBsYBkD8oofgyOV249Omh9wBuQpusvjIoFYeU1z7QGbmdj7msQsE18oP0HvyCcb8vHjSQp_9i_1-UnxZLT-fXy6uP15cnZ9dLyxXalwwaWUJzhhunOOSKUetNVyaqlZWNMYpwLJqfeUbyduqFr70plVSlA01eHFSfNjpbiYzeGfRWoJeb1I3G9EROv13JXR3eh2_adFUohYMBd7sBVL8OqEVPXTZ-h4n4OOUNVOKcqlKyhF9_Q96H6cU0B5SKMcYdv1ArXEWugttnOc7i-ozIYQUVLIGqXc7yqaYc_LtoWVG9Ry-nsPX-_ARf_WnzQP8O20E3u6Auy44-N79pxwGhn_DA82UUHVV_QJFP8GT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1973511369</pqid></control><display><type>article</type><title>Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Song, Yisheng ; Xuan, Yaoxian ; Zheng, Gaoli ; Xin, Yanfei ; Li, Lili ; Liu, Fang ; Chen, Hao ; Zhang, Sheng ; Chen, Zhiqin ; Xie, Feng ; Sun, Junying ; You, Zhenqiang ; Chen, Guocan</creator><contributor>Zakhary, Nadia I.</contributor><creatorcontrib>Song, Yisheng ; Xuan, Yaoxian ; Zheng, Gaoli ; Xin, Yanfei ; Li, Lili ; Liu, Fang ; Chen, Hao ; Zhang, Sheng ; Chen, Zhiqin ; Xie, Feng ; Sun, Junying ; You, Zhenqiang ; Chen, Guocan ; Zakhary, Nadia I.</creatorcontrib><description>Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5 ml/kg FPEs). Severe mammary gland hyperplasia was induced upon estradiol benzoate and progestin administration. FPEs could improve the pathological features of the animal model and reduce estrogen levels in the serum. Analysis of oxidant indices revealed that FPEs could increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, decrease malondialdehyde (MDA) level in the mammary glands and serum of the animal models, and decrease the proportion of cells positive for the oxidative DNA damage marker 8-oxo-dG in the mammary glands. Additionally, estradiol benzoate and progestin altered the levels of serum biochemical compounds such as aspartate transaminase (AST), total bilirubin (TBIL), and alanine transaminase (ALT), as well as hepatic oxidant indices such as SOD, GSH-Px, MDA, and 8-oxo-2′-deoxyguanosine (8-oxo-dG). These indices reverted to normal levels upon oral administration of a high dose of FPEs. Taken together, our results indicate that FPEs can protect the mammary glands and other visceral organs from oxidative damage.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2017/8235069</identifier><identifier>PMID: 29359010</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Antioxidants ; Bilirubin ; Breast cancer ; Cancer therapies ; Carica - chemistry ; Deoxyribonucleic acid ; DNA ; Drug dosages ; Estradiol ; Estrogens - toxicity ; Female ; Fermentation ; Functional foods & nutraceuticals ; Hyperplasia ; Hyperplasia - chemically induced ; Hyperplasia - drug therapy ; Laboratory animals ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - pathology ; Medical research ; Pharmaceuticals ; Phenols ; Plant Extracts - pharmacology ; Progestins - toxicity ; Protective Agents - pharmacology ; Rats ; Rats, Sprague-Dawley ; Rodents ; Superoxide ; Tumorigenesis ; Wound healing</subject><ispartof>Oxidative medicine and cellular longevity, 2017-01, Vol.2017 (2017), p.1-11</ispartof><rights>Copyright © 2017 Zhenqiang You et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Zhenqiang You et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Zhenqiang You et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-18c82adbb4bdd4819d0ccb48b369c57bd9a2ad9fe3e784f365e2ebf985270b4f3</citedby><cites>FETCH-LOGICAL-c499t-18c82adbb4bdd4819d0ccb48b369c57bd9a2ad9fe3e784f365e2ebf985270b4f3</cites><orcidid>0000-0003-0753-7604 ; 0000-0001-5364-4537 ; 0000-0003-2972-2704 ; 0000-0001-6624-9333 ; 0000-0003-0607-4986 ; 0000-0002-6921-3296 ; 0000-0002-1692-6735 ; 0000-0002-1335-4268 ; 0000-0002-6291-3097 ; 0000-0002-7538-9028 ; 0000-0002-1701-0702 ; 0000-0002-7973-7077</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735651/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735651/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29359010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zakhary, Nadia I.</contributor><creatorcontrib>Song, Yisheng</creatorcontrib><creatorcontrib>Xuan, Yaoxian</creatorcontrib><creatorcontrib>Zheng, Gaoli</creatorcontrib><creatorcontrib>Xin, Yanfei</creatorcontrib><creatorcontrib>Li, Lili</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Chen, Hao</creatorcontrib><creatorcontrib>Zhang, Sheng</creatorcontrib><creatorcontrib>Chen, Zhiqin</creatorcontrib><creatorcontrib>Xie, Feng</creatorcontrib><creatorcontrib>Sun, Junying</creatorcontrib><creatorcontrib>You, Zhenqiang</creatorcontrib><creatorcontrib>Chen, Guocan</creatorcontrib><title>Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5 ml/kg FPEs). Severe mammary gland hyperplasia was induced upon estradiol benzoate and progestin administration. FPEs could improve the pathological features of the animal model and reduce estrogen levels in the serum. Analysis of oxidant indices revealed that FPEs could increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, decrease malondialdehyde (MDA) level in the mammary glands and serum of the animal models, and decrease the proportion of cells positive for the oxidative DNA damage marker 8-oxo-dG in the mammary glands. Additionally, estradiol benzoate and progestin altered the levels of serum biochemical compounds such as aspartate transaminase (AST), total bilirubin (TBIL), and alanine transaminase (ALT), as well as hepatic oxidant indices such as SOD, GSH-Px, MDA, and 8-oxo-2′-deoxyguanosine (8-oxo-dG). These indices reverted to normal levels upon oral administration of a high dose of FPEs. Taken together, our results indicate that FPEs can protect the mammary glands and other visceral organs from oxidative damage.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Bilirubin</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Carica - chemistry</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug dosages</subject><subject>Estradiol</subject><subject>Estrogens - toxicity</subject><subject>Female</subject><subject>Fermentation</subject><subject>Functional foods & nutraceuticals</subject><subject>Hyperplasia</subject><subject>Hyperplasia - chemically induced</subject><subject>Hyperplasia - drug therapy</subject><subject>Laboratory animals</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - pathology</subject><subject>Medical research</subject><subject>Pharmaceuticals</subject><subject>Phenols</subject><subject>Plant Extracts - pharmacology</subject><subject>Progestins - toxicity</subject><subject>Protective Agents - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Superoxide</subject><subject>Tumorigenesis</subject><subject>Wound healing</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkd1rFDEUxQdRbK2--SwBXwRdm8wkM8mLUMpuW2ixiD6Hm4_ZTplJ1mRGXfCP9w67btUnIZCQ-8vJPfcUxUtG3zMmxGlJWXMqy0rQWj0qjpni5YIqxR8fzpQeFc9yvqe0rkrOnhZHpaqEooweFz9vopt6GGPakmXbejuS2JKVT4MPo3fkFjawBbL8MSawYyYxkBsYBkD8oofgyOV249Omh9wBuQpusvjIoFYeU1z7QGbmdj7msQsE18oP0HvyCcb8vHjSQp_9i_1-UnxZLT-fXy6uP15cnZ9dLyxXalwwaWUJzhhunOOSKUetNVyaqlZWNMYpwLJqfeUbyduqFr70plVSlA01eHFSfNjpbiYzeGfRWoJeb1I3G9EROv13JXR3eh2_adFUohYMBd7sBVL8OqEVPXTZ-h4n4OOUNVOKcqlKyhF9_Q96H6cU0B5SKMcYdv1ArXEWugttnOc7i-ozIYQUVLIGqXc7yqaYc_LtoWVG9Ry-nsPX-_ARf_WnzQP8O20E3u6Auy44-N79pxwGhn_DA82UUHVV_QJFP8GT</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Song, Yisheng</creator><creator>Xuan, Yaoxian</creator><creator>Zheng, Gaoli</creator><creator>Xin, Yanfei</creator><creator>Li, Lili</creator><creator>Liu, Fang</creator><creator>Chen, Hao</creator><creator>Zhang, Sheng</creator><creator>Chen, Zhiqin</creator><creator>Xie, Feng</creator><creator>Sun, Junying</creator><creator>You, Zhenqiang</creator><creator>Chen, Guocan</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0753-7604</orcidid><orcidid>https://orcid.org/0000-0001-5364-4537</orcidid><orcidid>https://orcid.org/0000-0003-2972-2704</orcidid><orcidid>https://orcid.org/0000-0001-6624-9333</orcidid><orcidid>https://orcid.org/0000-0003-0607-4986</orcidid><orcidid>https://orcid.org/0000-0002-6921-3296</orcidid><orcidid>https://orcid.org/0000-0002-1692-6735</orcidid><orcidid>https://orcid.org/0000-0002-1335-4268</orcidid><orcidid>https://orcid.org/0000-0002-6291-3097</orcidid><orcidid>https://orcid.org/0000-0002-7538-9028</orcidid><orcidid>https://orcid.org/0000-0002-1701-0702</orcidid><orcidid>https://orcid.org/0000-0002-7973-7077</orcidid></search><sort><creationdate>20170101</creationdate><title>Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats</title><author>Song, Yisheng ; Xuan, Yaoxian ; Zheng, Gaoli ; Xin, Yanfei ; Li, Lili ; Liu, Fang ; Chen, Hao ; Zhang, Sheng ; Chen, Zhiqin ; Xie, Feng ; Sun, Junying ; You, Zhenqiang ; Chen, Guocan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-18c82adbb4bdd4819d0ccb48b369c57bd9a2ad9fe3e784f365e2ebf985270b4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Bilirubin</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Carica - chemistry</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug dosages</topic><topic>Estradiol</topic><topic>Estrogens - toxicity</topic><topic>Female</topic><topic>Fermentation</topic><topic>Functional foods & nutraceuticals</topic><topic>Hyperplasia</topic><topic>Hyperplasia - chemically induced</topic><topic>Hyperplasia - drug therapy</topic><topic>Laboratory animals</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Glands, Animal - pathology</topic><topic>Medical research</topic><topic>Pharmaceuticals</topic><topic>Phenols</topic><topic>Plant Extracts - pharmacology</topic><topic>Progestins - toxicity</topic><topic>Protective Agents - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Superoxide</topic><topic>Tumorigenesis</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Yisheng</creatorcontrib><creatorcontrib>Xuan, Yaoxian</creatorcontrib><creatorcontrib>Zheng, Gaoli</creatorcontrib><creatorcontrib>Xin, Yanfei</creatorcontrib><creatorcontrib>Li, Lili</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Chen, Hao</creatorcontrib><creatorcontrib>Zhang, Sheng</creatorcontrib><creatorcontrib>Chen, Zhiqin</creatorcontrib><creatorcontrib>Xie, Feng</creatorcontrib><creatorcontrib>Sun, Junying</creatorcontrib><creatorcontrib>You, Zhenqiang</creatorcontrib><creatorcontrib>Chen, Guocan</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Yisheng</au><au>Xuan, Yaoxian</au><au>Zheng, Gaoli</au><au>Xin, Yanfei</au><au>Li, Lili</au><au>Liu, Fang</au><au>Chen, Hao</au><au>Zhang, Sheng</au><au>Chen, Zhiqin</au><au>Xie, Feng</au><au>Sun, Junying</au><au>You, Zhenqiang</au><au>Chen, Guocan</au><au>Zakhary, Nadia I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5 ml/kg FPEs). Severe mammary gland hyperplasia was induced upon estradiol benzoate and progestin administration. FPEs could improve the pathological features of the animal model and reduce estrogen levels in the serum. Analysis of oxidant indices revealed that FPEs could increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, decrease malondialdehyde (MDA) level in the mammary glands and serum of the animal models, and decrease the proportion of cells positive for the oxidative DNA damage marker 8-oxo-dG in the mammary glands. Additionally, estradiol benzoate and progestin altered the levels of serum biochemical compounds such as aspartate transaminase (AST), total bilirubin (TBIL), and alanine transaminase (ALT), as well as hepatic oxidant indices such as SOD, GSH-Px, MDA, and 8-oxo-2′-deoxyguanosine (8-oxo-dG). These indices reverted to normal levels upon oral administration of a high dose of FPEs. Taken together, our results indicate that FPEs can protect the mammary glands and other visceral organs from oxidative damage.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29359010</pmid><doi>10.1155/2017/8235069</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0753-7604</orcidid><orcidid>https://orcid.org/0000-0001-5364-4537</orcidid><orcidid>https://orcid.org/0000-0003-2972-2704</orcidid><orcidid>https://orcid.org/0000-0001-6624-9333</orcidid><orcidid>https://orcid.org/0000-0003-0607-4986</orcidid><orcidid>https://orcid.org/0000-0002-6921-3296</orcidid><orcidid>https://orcid.org/0000-0002-1692-6735</orcidid><orcidid>https://orcid.org/0000-0002-1335-4268</orcidid><orcidid>https://orcid.org/0000-0002-6291-3097</orcidid><orcidid>https://orcid.org/0000-0002-7538-9028</orcidid><orcidid>https://orcid.org/0000-0002-1701-0702</orcidid><orcidid>https://orcid.org/0000-0002-7973-7077</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1942-0900 |
| ispartof | Oxidative medicine and cellular longevity, 2017-01, Vol.2017 (2017), p.1-11 |
| issn | 1942-0900 1942-0994 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5735651 |
| source | MEDLINE; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antioxidants Bilirubin Breast cancer Cancer therapies Carica - chemistry Deoxyribonucleic acid DNA Drug dosages Estradiol Estrogens - toxicity Female Fermentation Functional foods & nutraceuticals Hyperplasia Hyperplasia - chemically induced Hyperplasia - drug therapy Laboratory animals Mammary Glands, Animal - drug effects Mammary Glands, Animal - pathology Medical research Pharmaceuticals Phenols Plant Extracts - pharmacology Progestins - toxicity Protective Agents - pharmacology Rats Rats, Sprague-Dawley Rodents Superoxide Tumorigenesis Wound healing |
| title | Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T22%3A31%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modulatory%20Effect%20of%20Fermented%20Papaya%20Extracts%20on%20Mammary%20Gland%20Hyperplasia%20Induced%20by%20Estrogen%20and%20Progestin%20in%20Female%20Rats&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=Song,%20Yisheng&rft.date=2017-01-01&rft.volume=2017&rft.issue=2017&rft.spage=1&rft.epage=11&rft.pages=1-11&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2017/8235069&rft_dat=%3Cgale_pubme%3EA555850817%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1973511369&rft_id=info:pmid/29359010&rft_galeid=A555850817&rfr_iscdi=true |