Epigenetic modification of miR-663 controls mitochondria-to-nucleus retrograde signaling and tumor progression

The normal cellular function requires communication between mitochondria and the nucleus, termed mitochondria-to-nucleus retrograde signaling. Disruption of this mechanism has been implicated in the development of cancers. Many proteins are known modulators of retrograde signaling, but whether micro...

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Veröffentlicht in:	The Journal of biological chemistry 2017-12, Vol.292 (50), p.20694-20706
Hauptverfasser:	Carden, Trevor, Singh, Bhupendra, Mooga, Ved, Bajpai, Prachi, Singh, Keshav K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals breast cancer Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Nucleus - pathology DNA methylation DNA, Mitochondrial - metabolism Enzyme Inhibitors - pharmacology Epigenesis, Genetic - drug effects Female Gene Deletion gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulation Humans Mice, Nude microRNA (miRNA) MicroRNAs - antagonists & inhibitors MicroRNAs - metabolism miR-663 mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Neoplasm Transplantation Oxidative Phosphorylation - drug effects Oxidative Stress - drug effects OXPHOS retrograde signaling RNA - metabolism RNA, Neoplasm - antagonists & inhibitors RNA, Neoplasm - metabolism Signal Transduction - drug effects Tumor Burden tumorigenesis
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