Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors

Lymphangioleiomyomatosis (LAM) is a fatal lung disease associated with germline or somatic inactivating mutations in tuberous sclerosis complex genes (TSC1 or TSC2). LAM is characterized by neoplastic growth of smooth muscle-α-actin–positive cells that destroy lung parenchyma and by the formation of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2017-12, Vol.292 (50), p.20528-20543
Hauptverfasser:	Stepanova, Victoria, Dergilev, Konstantin V., Holman, Kelci R., Parfyonova, Yelena V., Tsokolaeva, Zoya I., Teter, Mimi, Atochina-Vasserman, Elena N., Volgina, Alla, Zaitsev, Sergei V., Lewis, Shane P., Zabozlaev, Fedor G., Obraztsova, Kseniya, Krymskaya, Vera P., Cines, Douglas B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiomyolipoma - drug therapy Angiomyolipoma - genetics Angiomyolipoma - metabolism Angiomyolipoma - pathology Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Line, Tumor Gene Expression Regulation, Neoplastic - drug effects Humans Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology lung Lung - drug effects Lung - metabolism Lung - pathology Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphangioleiomyomatosis - drug therapy Lymphangioleiomyomatosis - genetics Lymphangioleiomyomatosis - metabolism Lymphangioleiomyomatosis - pathology mammalian target of rapamycin (mTOR) Mice, Inbred C57BL Mice, Knockout Molecular Bases of Disease mTOR complex (mTORC) Mutation Neoplasm Invasiveness - pathology Neoplasm Invasiveness - prevention & control Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Transplantation plasminogen RNA Interference TOR complex (TORC) tuberous sclerosis complex (TSC) Tuberous Sclerosis Complex 1 Protein Tuberous Sclerosis Complex 2 Protein Tumor Burden - drug effects tumor cell biology Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism urokinase receptor Urokinase-Type Plasminogen Activator - antagonists & inhibitors Urokinase-Type Plasminogen Activator - genetics Urokinase-Type Plasminogen Activator - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!