Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells

Piplartine (piperlongumine) is a plant-derived molecule that has been receiving intense interest due to its anticancer characteristics that target the oxidative stress. In the present paper, two novel piplartine-containing ruthenium complexes [Ru(piplartine)(dppf)(bipy)](PF ) (1) and [Ru(piplartine)...

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Veröffentlicht in:Oncotarget 2017-11, Vol.8 (61), p.104367-104392
Hauptverfasser: D'Sousa Costa, Cinara O, Araujo Neto, João H, Baliza, Ingrid R S, Dias, Rosane B, Valverde, Ludmila de F, Vidal, Manuela T A, Sales, Caroline B S, Rocha, Clarissa A G, Moreira, Diogo R M, Soares, Milena B P, Batista, Alzir A, Bezerra, Daniel P
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Sprache:eng
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