Cholesterol overload in the liver aggravates oxidative stress-mediated DNA damage and accelerates hepatocarcinogenesis

Primary liver cancers represent the second leading cause of cancer-related deaths worldwide. Diverse etiological factors include chronic viral hepatitis, aflatoxin and alcohol exposure as well as aberrant liver lipid overload. Cholesterol has been identified as a key inducer of metabolic impairment,...

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Veröffentlicht in:Oncotarget 2017-11, Vol.8 (61), p.104136-104148
Hauptverfasser: Enríquez-Cortina, Cristina, Bello-Monroy, Oscar, Rosales-Cruz, Patricia, Souza, Verónica, Miranda, Roxana U, Toledo-Pérez, Rafael, Luna-López, Armando, Simoni-Nieves, Arturo, Hernández-Pando, Rogelio, Gutiérrez-Ruiz, María Concepción, Calvisi, Diego F, Marquardt, Jens U, Bucio, Leticia, Gomez-Quiroz, Luis Enrique
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Sprache:eng
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