An Implantable Micro-Caged Device for Direct Local Delivery of Agents
Local and controlled delivery of therapeutic agents directly into focally afflicted tissues is the ideal for the treatment of diseases that require direct interventions. However, current options are obtrusive, difficult to implement, and limited in their scope of utilization; the optimal solution re...
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| Veröffentlicht in: | Scientific reports 2017-12, Vol.7 (1), p.17624-16, Article 17624 |
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| creator | Son, Alexander I. Opfermann, Justin D. McCue, Caroline Ziobro, Julie Abrahams, John H. Jones, Katherine Morton, Paul D. Ishii, Seiji Oluigbo, Chima Krieger, Axel Liu, Judy S. Hashimoto-Torii, Kazue Torii, Masaaki |
| description | Local and controlled delivery of therapeutic agents directly into focally afflicted tissues is the ideal for the treatment of diseases that require direct interventions. However, current options are obtrusive, difficult to implement, and limited in their scope of utilization; the optimal solution requires a method that may be optimized for available therapies and is designed for exact delivery. To address these needs, we propose the Biocage, a customizable implantable local drug delivery platform. The device is a needle-sized porous container capable of encasing therapeutic molecules and matrices of interest to be eluted into the region of interest over time. The Biocage was fabricated using the Nanoscribe Photonic Professional GT 3D laser lithography system, a two-photon polymerization (2PP) 3D printer capable of micron-level precision on a millimeter scale. We demonstrate the build consistency and features of the fabricated device; its ability to release molecules; and a method for its accurate, stable delivery in mouse brain tissue. The Biocage provides a powerful tool for customizable and precise delivery of therapeutic agents into target tissues. |
| doi_str_mv | 10.1038/s41598-017-17912-y |
| format | Article |
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However, current options are obtrusive, difficult to implement, and limited in their scope of utilization; the optimal solution requires a method that may be optimized for available therapies and is designed for exact delivery. To address these needs, we propose the Biocage, a customizable implantable local drug delivery platform. The device is a needle-sized porous container capable of encasing therapeutic molecules and matrices of interest to be eluted into the region of interest over time. The Biocage was fabricated using the Nanoscribe Photonic Professional GT 3D laser lithography system, a two-photon polymerization (2PP) 3D printer capable of micron-level precision on a millimeter scale. We demonstrate the build consistency and features of the fabricated device; its ability to release molecules; and a method for its accurate, stable delivery in mouse brain tissue. The Biocage provides a powerful tool for customizable and precise delivery of therapeutic agents into target tissues.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-17912-y</identifier><identifier>PMID: 29247175</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 14/19 ; 14/28 ; 14/34 ; 14/63 ; 142/126 ; 3-D printers ; 631/154/152 ; 631/61/2296 ; Animal tissues ; Animals ; Design ; Drug delivery ; Drug delivery systems ; Drug Delivery Systems - instrumentation ; Drug Delivery Systems - methods ; Glass substrates ; Humanities and Social Sciences ; Lasers ; Medical treatment ; Medicine ; Mice ; Mice, Inbred C57BL ; multidisciplinary ; Neurosciences ; Pharmaceutical Preparations - administration & dosage ; Polymerization ; Printing, Three-Dimensional ; Science ; Science (multidisciplinary) ; Sepharose - administration & dosage</subject><ispartof>Scientific reports, 2017-12, Vol.7 (1), p.17624-16, Article 17624</ispartof><rights>The Author(s) 2017</rights><rights>2017. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-5b014951a54ba557910254ac7f006768db7ffcb725985f0da6499268f1a1bd83</citedby><cites>FETCH-LOGICAL-c540t-5b014951a54ba557910254ac7f006768db7ffcb725985f0da6499268f1a1bd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732160/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732160/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29247175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Son, Alexander I.</creatorcontrib><creatorcontrib>Opfermann, Justin D.</creatorcontrib><creatorcontrib>McCue, Caroline</creatorcontrib><creatorcontrib>Ziobro, Julie</creatorcontrib><creatorcontrib>Abrahams, John H.</creatorcontrib><creatorcontrib>Jones, Katherine</creatorcontrib><creatorcontrib>Morton, Paul D.</creatorcontrib><creatorcontrib>Ishii, Seiji</creatorcontrib><creatorcontrib>Oluigbo, Chima</creatorcontrib><creatorcontrib>Krieger, Axel</creatorcontrib><creatorcontrib>Liu, Judy S.</creatorcontrib><creatorcontrib>Hashimoto-Torii, Kazue</creatorcontrib><creatorcontrib>Torii, Masaaki</creatorcontrib><title>An Implantable Micro-Caged Device for Direct Local Delivery of Agents</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Local and controlled delivery of therapeutic agents directly into focally afflicted tissues is the ideal for the treatment of diseases that require direct interventions. However, current options are obtrusive, difficult to implement, and limited in their scope of utilization; the optimal solution requires a method that may be optimized for available therapies and is designed for exact delivery. To address these needs, we propose the Biocage, a customizable implantable local drug delivery platform. The device is a needle-sized porous container capable of encasing therapeutic molecules and matrices of interest to be eluted into the region of interest over time. The Biocage was fabricated using the Nanoscribe Photonic Professional GT 3D laser lithography system, a two-photon polymerization (2PP) 3D printer capable of micron-level precision on a millimeter scale. We demonstrate the build consistency and features of the fabricated device; its ability to release molecules; and a method for its accurate, stable delivery in mouse brain tissue. The Biocage provides a powerful tool for customizable and precise delivery of therapeutic agents into target tissues.</description><subject>13</subject><subject>14/19</subject><subject>14/28</subject><subject>14/34</subject><subject>14/63</subject><subject>142/126</subject><subject>3-D printers</subject><subject>631/154/152</subject><subject>631/61/2296</subject><subject>Animal tissues</subject><subject>Animals</subject><subject>Design</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Drug Delivery Systems - methods</subject><subject>Glass substrates</subject><subject>Humanities and Social Sciences</subject><subject>Lasers</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>multidisciplinary</subject><subject>Neurosciences</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Polymerization</subject><subject>Printing, Three-Dimensional</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sepharose - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Son, Alexander I.</au><au>Opfermann, Justin D.</au><au>McCue, Caroline</au><au>Ziobro, Julie</au><au>Abrahams, John H.</au><au>Jones, Katherine</au><au>Morton, Paul D.</au><au>Ishii, Seiji</au><au>Oluigbo, Chima</au><au>Krieger, Axel</au><au>Liu, Judy S.</au><au>Hashimoto-Torii, Kazue</au><au>Torii, Masaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Implantable Micro-Caged Device for Direct Local Delivery of Agents</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-12-15</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>17624</spage><epage>16</epage><pages>17624-16</pages><artnum>17624</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Local and controlled delivery of therapeutic agents directly into focally afflicted tissues is the ideal for the treatment of diseases that require direct interventions. However, current options are obtrusive, difficult to implement, and limited in their scope of utilization; the optimal solution requires a method that may be optimized for available therapies and is designed for exact delivery. To address these needs, we propose the Biocage, a customizable implantable local drug delivery platform. The device is a needle-sized porous container capable of encasing therapeutic molecules and matrices of interest to be eluted into the region of interest over time. The Biocage was fabricated using the Nanoscribe Photonic Professional GT 3D laser lithography system, a two-photon polymerization (2PP) 3D printer capable of micron-level precision on a millimeter scale. We demonstrate the build consistency and features of the fabricated device; its ability to release molecules; and a method for its accurate, stable delivery in mouse brain tissue. The Biocage provides a powerful tool for customizable and precise delivery of therapeutic agents into target tissues.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29247175</pmid><doi>10.1038/s41598-017-17912-y</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13 14/19 14/28 14/34 14/63 142/126 3-D printers 631/154/152 631/61/2296 Animal tissues Animals Design Drug delivery Drug delivery systems Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Glass substrates Humanities and Social Sciences Lasers Medical treatment Medicine Mice Mice, Inbred C57BL multidisciplinary Neurosciences Pharmaceutical Preparations - administration & dosage Polymerization Printing, Three-Dimensional Science Science (multidisciplinary) Sepharose - administration & dosage |
| title | An Implantable Micro-Caged Device for Direct Local Delivery of Agents |
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