Steroidogenesis in Leydig cells: effects of aging and environmental factors

Serum testosterone (TS) levels decrease with aging in both humans and rodents. Using the rat as a model system, it was found that age-related reductions in serum TS were not due to loss of Leydig cells, but rather to the reduced ability of the Leydig cells to produce TS in response to luteinizing ho...

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Veröffentlicht in:	Reproduction (Cambridge, England) England), 2017-10, Vol.154 (4), p.R111-R122
Hauptverfasser:	Wang, Yiyan, Chen, Fenfen, Ye, Leping, Zirkin, Barry, Chen, Haolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging - blood Aging - metabolism Animals Cholesterol - metabolism Cyclic AMP - metabolism Endocrine Disruptors - pharmacology Environment Humans Leydig Cells - drug effects Leydig Cells - metabolism Luteinizing Hormone - metabolism Male Mitochondria - metabolism Oxidative Stress Review Testosterone - biosynthesis Testosterone - blood Testosterone - deficiency
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