Steroidogenesis in Leydig cells: effects of aging and environmental factors
Serum testosterone (TS) levels decrease with aging in both humans and rodents. Using the rat as a model system, it was found that age-related reductions in serum TS were not due to loss of Leydig cells, but rather to the reduced ability of the Leydig cells to produce TS in response to luteinizing ho...
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| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2017-10, Vol.154 (4), p.R111-R122 |
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| container_title | Reproduction (Cambridge, England) |
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| creator | Wang, Yiyan Chen, Fenfen Ye, Leping Zirkin, Barry Chen, Haolin |
| description | Serum testosterone (TS) levels decrease with aging in both humans and rodents. Using the rat as a model system, it was found that age-related reductions in serum TS were not due to loss of Leydig cells, but rather to the reduced ability of the Leydig cells to produce TS in response to luteinizing hormone (LH). Detailed analyses of the steroidogenic pathway have suggested that two defects along the pathway, LH-stimulated cAMP production and cholesterol transport to and into the mitochondria, are of particular importance in age-related reductions in TS production. Although the mechanisms involved in these defects are far from certain, increasing oxidative stress appears to play a particularly important role. Interestingly, increased oxidative stress also appears to be involved in the suppressive effects of endocrine disruptors on Leydig cell TS production. |
| doi_str_mv | 10.1530/REP-17-0064 |
| format | Article |
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Using the rat as a model system, it was found that age-related reductions in serum TS were not due to loss of Leydig cells, but rather to the reduced ability of the Leydig cells to produce TS in response to luteinizing hormone (LH). Detailed analyses of the steroidogenic pathway have suggested that two defects along the pathway, LH-stimulated cAMP production and cholesterol transport to and into the mitochondria, are of particular importance in age-related reductions in TS production. Although the mechanisms involved in these defects are far from certain, increasing oxidative stress appears to play a particularly important role. Interestingly, increased oxidative stress also appears to be involved in the suppressive effects of endocrine disruptors on Leydig cell TS production.</description><identifier>ISSN: 1470-1626</identifier><identifier>EISSN: 1741-7899</identifier><identifier>DOI: 10.1530/REP-17-0064</identifier><identifier>PMID: 28747539</identifier><language>eng</language><publisher>England: Bioscientifica Ltd</publisher><subject>Age Factors ; Aging - blood ; Aging - metabolism ; Animals ; Cholesterol - metabolism ; Cyclic AMP - metabolism ; Endocrine Disruptors - pharmacology ; Environment ; Humans ; Leydig Cells - drug effects ; Leydig Cells - metabolism ; Luteinizing Hormone - metabolism ; Male ; Mitochondria - metabolism ; Oxidative Stress ; Review ; Testosterone - biosynthesis ; Testosterone - blood ; Testosterone - deficiency</subject><ispartof>Reproduction (Cambridge, England), 2017-10, Vol.154 (4), p.R111-R122</ispartof><rights>2017 Society for Reproduction and Fertility</rights><rights>2017 Society for Reproduction and Fertility.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b489t-c79124fcd0820087c41b1052118f57e2f0d4a59e7c5a3f03da2f2bd61dc9784e3</citedby><cites>FETCH-LOGICAL-b489t-c79124fcd0820087c41b1052118f57e2f0d4a59e7c5a3f03da2f2bd61dc9784e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28747539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yiyan</creatorcontrib><creatorcontrib>Chen, Fenfen</creatorcontrib><creatorcontrib>Ye, Leping</creatorcontrib><creatorcontrib>Zirkin, Barry</creatorcontrib><creatorcontrib>Chen, Haolin</creatorcontrib><title>Steroidogenesis in Leydig cells: effects of aging and environmental factors</title><title>Reproduction (Cambridge, England)</title><addtitle>Reproduction</addtitle><description>Serum testosterone (TS) levels decrease with aging in both humans and rodents. Using the rat as a model system, it was found that age-related reductions in serum TS were not due to loss of Leydig cells, but rather to the reduced ability of the Leydig cells to produce TS in response to luteinizing hormone (LH). Detailed analyses of the steroidogenic pathway have suggested that two defects along the pathway, LH-stimulated cAMP production and cholesterol transport to and into the mitochondria, are of particular importance in age-related reductions in TS production. Although the mechanisms involved in these defects are far from certain, increasing oxidative stress appears to play a particularly important role. Interestingly, increased oxidative stress also appears to be involved in the suppressive effects of endocrine disruptors on Leydig cell TS production.</description><subject>Age Factors</subject><subject>Aging - blood</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Cholesterol - metabolism</subject><subject>Cyclic AMP - metabolism</subject><subject>Endocrine Disruptors - pharmacology</subject><subject>Environment</subject><subject>Humans</subject><subject>Leydig Cells - drug effects</subject><subject>Leydig Cells - metabolism</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Male</subject><subject>Mitochondria - metabolism</subject><subject>Oxidative Stress</subject><subject>Review</subject><subject>Testosterone - biosynthesis</subject><subject>Testosterone - blood</subject><subject>Testosterone - deficiency</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFTEUhoMotlZX7iVLQUZzMskkcSGUUj_ohRY_1iGTnIyRuUlN5hb6753LrUU3XeVAHp7znpeQl8DeguzZu6_nVx2ojrFBPCLHoAR0ShvzeJ2FYh0MfDgiz1r7xRhIrYan5IhrJZTszTG5-LZgLSmUCTO21GjKdIO3IU3U4zy39xRjRL80WiJ1U8oTdTlQzDeplrzFvLiZRueXUttz8iS6ueGLu_eE_Ph4_v3sc7e5_PTl7HTTjUKbpfPKABfRB6Y5Y1p5ASMwyQF0lAp5ZEE4aVB56frI-uB45GMYIHijtMD-hHw4eK934xaDX0NUN9vrmrau3trikv3_J6efdio3VqoehJar4PWdoJbfO2yL3aa2P9dlLLtmwXAhjeCDWtE3B9TX0lrFeL8GmN3Xb9f6LSi7r3-lX_2b7J792_cKwAEYU2k-rflSTN49KP0D_aWReg</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Wang, Yiyan</creator><creator>Chen, Fenfen</creator><creator>Ye, Leping</creator><creator>Zirkin, Barry</creator><creator>Chen, Haolin</creator><general>Bioscientifica Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171001</creationdate><title>Steroidogenesis in Leydig cells: effects of aging and environmental factors</title><author>Wang, Yiyan ; Chen, Fenfen ; Ye, Leping ; Zirkin, Barry ; Chen, Haolin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b489t-c79124fcd0820087c41b1052118f57e2f0d4a59e7c5a3f03da2f2bd61dc9784e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age Factors</topic><topic>Aging - blood</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Cholesterol - metabolism</topic><topic>Cyclic AMP - metabolism</topic><topic>Endocrine Disruptors - pharmacology</topic><topic>Environment</topic><topic>Humans</topic><topic>Leydig Cells - drug effects</topic><topic>Leydig Cells - metabolism</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Male</topic><topic>Mitochondria - metabolism</topic><topic>Oxidative Stress</topic><topic>Review</topic><topic>Testosterone - biosynthesis</topic><topic>Testosterone - blood</topic><topic>Testosterone - deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yiyan</creatorcontrib><creatorcontrib>Chen, Fenfen</creatorcontrib><creatorcontrib>Ye, Leping</creatorcontrib><creatorcontrib>Zirkin, Barry</creatorcontrib><creatorcontrib>Chen, Haolin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yiyan</au><au>Chen, Fenfen</au><au>Ye, Leping</au><au>Zirkin, Barry</au><au>Chen, Haolin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Steroidogenesis in Leydig cells: effects of aging and environmental factors</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>154</volume><issue>4</issue><spage>R111</spage><epage>R122</epage><pages>R111-R122</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>Serum testosterone (TS) levels decrease with aging in both humans and rodents. 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| ispartof | Reproduction (Cambridge, England), 2017-10, Vol.154 (4), p.R111-R122 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Age Factors Aging - blood Aging - metabolism Animals Cholesterol - metabolism Cyclic AMP - metabolism Endocrine Disruptors - pharmacology Environment Humans Leydig Cells - drug effects Leydig Cells - metabolism Luteinizing Hormone - metabolism Male Mitochondria - metabolism Oxidative Stress Review Testosterone - biosynthesis Testosterone - blood Testosterone - deficiency |
| title | Steroidogenesis in Leydig cells: effects of aging and environmental factors |
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