miR-199a modulates cisplatin resistance in ovarian cancer by targeting Hif1α

Resistance to chemotherapy is a primary problem for the effective treatment of ovarian cancer. Recently, increasing evidence has demonstrated that miRNAs modulate many important molecular pathways involved in chemotherapy. Previous studies demonstrated that miR-199a affected ovarian cancer cell resi...

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Veröffentlicht in:	OncoTargets and therapy 2017-01, Vol.10, p.5899-5906
Hauptverfasser:	Feng, Xue, Liu, Ning, Deng, Suo, Zhang, Dandan, Wang, Kexin, Lu, Meisong
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis BAX protein Binding sites Bone surgery Cancer therapies Caspase-8 Chemotherapy Chronic obstructive pulmonary disease Cisplatin Enzyme-linked immunosorbent assay Enzymes Flow cytometry Hypoxia Hypoxia-inducible factor 1a Hypoxia-inducible factors Immunoglobulins MicroRNAs Original Research Ovarian cancer Proteins Reverse transcription Transfection Tumor cell lines Tumor necrosis factor-TNF Womens health
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