Tonic inhibition of brown adipose tissue sympathetic nerve activity via muscarinic acetylcholine receptors in the rostral raphe pallidus

Key points A tonically active, muscarinic cholinergic inhibition of rostral raphe pallidus (rRPa) neurons influences thermogenesis of brown adipose tissue (BAT) independent of ambient temperature conditions. The tonically active cholinergic input to rRPa originates caudal to the hypothalamus. Muscar...

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Veröffentlicht in:	The Journal of physiology 2017-12, Vol.595 (24), p.7495-7508
Hauptverfasser:	Conceição, Ellen Paula Santos, Madden, Christopher J., Morrison, Shaun F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine receptors (muscarinic) Activation Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - innervation Adipose Tissue, Brown - physiology Animals Body temperature Carbon dioxide Cholinesterase Cholinesterase inhibitors Cholinesterase Inhibitors - pharmacology Energy expenditure Glutamic acid receptors Heart rate Hypothalamus Male Medulla oblongata Muscarinic Agonists - pharmacology Muscarinic Antagonists - pharmacology Neostigmine Neostigmine - pharmacology Neural Inhibition Neurons Neuroscience ‐ behavioural/systems/cognitive Nucleus Raphe Pallidus - physiology Oxotremorine Oxotremorine - pharmacology Rats Rats, Sprague-Dawley Receptor mechanisms Receptors, Muscarinic - metabolism Reflexes Research Paper Rodents Scopolamine Sympathetic Nervous System - drug effects Sympathetic Nervous System - metabolism Sympathetic Nervous System - physiology Temperature effects Thermogenesis thermoregulation γ-Aminobutyric acid γ-Aminobutyric acid receptors
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