Immune microenvironment of experimental rat C6 gliomas resembles human glioblastomas

Glioblastoma (GBM) is the most aggressive primary brain tumor, with ineffective anti-tumor responses and a poor prognosis despite aggressive treatments. GBM immune microenvironment is heterogenous and activation of specific immune populations in GBM is not fully characterized. Reliable animal model...

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Veröffentlicht in:	Scientific reports 2017-12, Vol.7 (1), p.17556-14, Article 17556
Hauptverfasser:	Gieryng, Anna, Pszczolkowska, Dominika, Bocian, Katarzyna, Dabrowski, Michal, Rajan, Wenson David, Kloss, Michal, Mieczkowski, Jakub, Kaminska, Bozena
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/51 38 38/61 38/90 45/77 631/114/2404 631/67/327 64 Animal models Animals Brain cancer Brain Neoplasms - genetics Brain Neoplasms - immunology Brain Neoplasms - pathology Brain tumors CD11b antigen Cell Line, Tumor Cytotoxicity Flow cytometry Gene Expression Profiling Glioblastoma Glioblastoma - genetics Glioblastoma - immunology Glioblastoma - pathology Glioma Glioma cells Humanities and Social Sciences Humans Immune Evasion Immune system Immunosuppression Lymphocytes Lymphocytes T Macrophages Male Metastases Microglia Microglia - metabolism multidisciplinary Myeloid cells Rats Rats, Wistar Science Science (multidisciplinary) Species Specificity Subpopulations Transcription Transcription, Genetic Tumor Microenvironment - immunology
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