IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer

Background: Activated type 1 insulin-like growth factor receptors (IGF-1Rs) undergo internalisation and nuclear translocation, promoting cell survival. We previously reported that IGF-1R inhibition delays DNA damage repair, sensitising prostate cancer cells to ionising radiation. Here we tested the...

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Veröffentlicht in:	British journal of cancer 2017-11, Vol.117 (11), p.1600-1606
Hauptverfasser:	Aleksic, Tamara, Verrill, Clare, Bryant, Richard J, Han, Cheng, Worrall, Andrew Ross, Brureau, Laurent, Larré, Stephane, Higgins, Geoff S, Fazal, Fahad, Sabbagh, Ahmad, Haider, Syed, Buffa, Francesca M, Cole, David, Macaulay, Valentine M
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028/67/589/466 692/53/2423 Aged Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell survival Clinical Study DNA damage DNA repair Drug Resistance Epidemiology Growth factor receptors Humans Immunohistochemistry Insulin Insulin-like growth factor receptors Insulin-like growth factors Ionizing radiation Male Metastases Middle Aged Molecular Medicine Multivariate analysis Neoplasm Recurrence, Local Neoplasm Staging Nuclear transport Oncology Prostate cancer Prostatectomy Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Radiation therapy Radioresistance Receptor, IGF Type 1 - analysis Receptor, IGF Type 1 - physiology Transcription Translocation Tumors
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